Chromosome Metabolism and Cancer Training Grant

项目总结/摘要 这个修订后的申请寻求更新的染色体代谢和癌症培训补助金（CMCTG） 在弗雷德哈钦森癌症研究中心（弗雷德哈奇），一个国家癌症研究所指定的综合癌症 中心该培训计划通过以下方式弥合基础和转化癌症研究之间的差距： 在全国首屈一指的癌症研究机构之一， 弗雷德哈钦森癌症研究中心（弗雷德哈奇），并利用协同作用出现的一个 正在进行的非常广泛的研究。CMCTG是弗雷德·哈奇唯一的机构培训补助金 (T32)主要研究癌症的分子机制。26名培训教员包括4名初级 正在被培养为下一代研究导师的教师。在22名高级 培训师，四个是国家科学院的成员，三个是霍华德休斯医疗 研究所研究员。所有的培训教师都有积极的研究计划和外部资金， 大多数都得到了NCI、ACS、DoD或癌症基金会的支持。该计划由PI管理， 助理PI和一个指导委员会，包括四名培训教师和办公室主任， 科学职业发展和外部顾问。该计划的目标是培养年轻科学家 在癌症研究的职业生涯中，特别强调研究基础分子和细胞 正常细胞和癌细胞的生物学。我们的培训计划是基于预防， 癌症的诊断和治疗将需要对分子机制的深刻理解， 作为正常细胞行为的基础，并驱动肿瘤及其 环境培训在综合园区的小型专用研究实验室进行， 监督学员的进度，有效指导培训学院的初级成员，并经常 学员和导师之间的思想交流。广泛的核心设施支持尖端研究。超过 在过去的10年里，CMCTG已经影响了11名博士前和35名博士后学员的职业生涯， 其中2个predocs和6个postdocs仍然支持。9名受训人员来自代表人数不足的少数族裔 组在过去的38名受训人员中，8名是大学研究或教学的初级教师，8名是科学家 或在学术环境中的科学管理，5人在生物技术领域拥有研究职位，14人仍在 弗雷德·哈奇或其他机构，1人死亡，1人休病假，1人是家庭主妇。七 博士后学员获得了美国癌症协会的独立研究奖学金， 博士前培训生赢得了著名的国家科学基金会博士前奖学金。我们计划继续保持这一成功记录 未来

Project Summary/Abstract This revised application seeks renewal of the Chromosome Metabolism and Cancer Training Grant (CMCTG) at the Fred Hutchinson Cancer Research Center (Fred Hutch), an NCI-designated Comprehensive Cancer Center. The training program bridges the gap between basic and translational cancer research by bringing together young translational and basic scientists in one of the nation’s premier cancer research institutions, the Fred Hutchinson Cancer Research Center (Fred Hutch), and leverages the synergies emerging from an extraordinarily wide range of ongoing research. The CMCTG is the only Fred Hutch institutional training grant (T32) that is focused on molecular mechanisms of cancer. The 26 training faculty members include four junior faculty members who are being developed as the next generation of research mentors. Of the 22 senior trainers, four are members of the National Academy of Sciences and three are Howard Hughes Medical Institute Investigators. All of the training faculty have vigorous research programs and external funding, and most have support from the NCI, ACS, DoD or cancer foundations. The program is administered by the PI and Assistant PI and a Steering Committee comprising four of the training faculty plus the head of the Office of Scientific Career Development and an External Advisor. The goal of the program is to train young scientists toward a career in cancer research with special emphasis on investigating fundamental molecular and cell biology of normal and cancer cells. Our training program is based on the concept that the prevention, diagnosis, and treatment of cancer will require a profound understanding of the molecular mechanisms that underlie the behavior of normal cells and drive the initiation, progression, and maintenance of tumors and their environment. Training occurs in small, dedicated research labs on an integrated campus, allowing close monitoring of trainee progress, effective mentoring of junior members of the Training Faculty, and frequent exchange of ideas between trainees and mentors. Extensive core facilities support cutting-edge research. Over the past 10 years, the CMCTG has impacted the careers of 11 pre-doctoral and 35 postdoctoral trainees, of whom 2 predocs and 6 postdocs are still supported. 9 trainees are/were from under-represented minority groups. Of the 38 past trainees, 8 are junior faculty in research or teaching at universities, 8 are staff scientists or in science administration in academic settings, 5 have research positions in biotech, 14 remain in training at Fred Hutch or other institutions, 1 is deceased, 1 is on medical leave, and 1 is a homemaker. Seven postdoctoral trainees obtained independent research fellowships from the American Cancer Society, and four predoctoral trainees won prestigious NSF predoctoral fellowships. We plan to continue this record of success into the future.