Core A: Administrative Core

项目摘要(核心A--行政核心) 这项建议的总体目标是：(1)建立健壮、一致和安全的无艺术状态 SIV和SIV感染恒河猴通过持续表达 抗体和抗体样抑制物，(2)了解猕猴免疫系统和 抗逆转录病毒治疗促进这些功能性治疗，以及(3)确定这些功能性治疗是否可以 也有助于加速潜伏感染细胞储存库的腐烂。行政核心意志 提供一切必要的后勤、科学、管理、统计、监管和财政支持 促进和协调本计划的研究，从而确保这些目标的顺利完成。 行政核心还将设立一个具有广泛代表性的管理委员会并为其活动提供便利 非人灵长类研究和腺相关病毒(AAV)载体应用于 病毒感染的治疗和预防。这个管理委员会将每季度召开一次会议，两次 被任命为科学顾问和NIH项目官员，并两次独立。行政核心 威尔促成了这些会议。核心还将通过涵盖以下内容促进跨项目协作 涉及多项目合作的所有手稿的出版费用对本组织的目标至关重要 建议，并确保对本计划中描述的所有研究提供统计支持。最后，核心将 负责遵守动物护理和使用、财务和报告要求 与此计划相关联。

PROJECT SUMMARY (Core A – Administrative Core) The general goals of this proposal are: (1) to establish robust, consistent, and safe states of ART-free remission (‘functional cures’) in SHIV- and SIV-infected rhesus macaques through sustained expression of antibodies and antibody-like inhibitors, (2) to understand the role of the macaque immune system and antiretroviral therapy in facilitating these functional cures, and (3) to determine if these functional cures can also help accelerate the decay of the reservoir of latently infected cells. The Administrative Core will provide all the logistic, scientific, managerial, statistical, regulatory and financial support necessary to facilitate and coordinate the studies of this program, thus ensuring the successful completion of these goals. The Administrative Core will also establish and facilitate the activities of a Governing Committee with broad experience in non-human primate studies and in the application of adeno-associated virus (AAV) vectors to the treatment and prevention of viral infection. This Governing Committee will meet quarterly, twice with an appointed Scientific Advisory and NIH Program officials, and twice independently. The Administrative Core will facilitated these meetings. The Core will also promote cross-project collaborations by covering the publication costs of all manuscripts involving multi-project collaborations central to the goals of this proposal, and ensure statistical support for all studies described in this program. Finally the Core will assume responsibility for compliance with animal care and use, financial, and reporting requirements associated with this program.