ABCD-USA Consortium: Coordinating Center

项目总结 在最初的资助期，ABCD财团使用严格的流行病学方法招募了不同的 我们通过21个研究站点对11,878名9至10岁的儿童进行了抽样调查，其中2,136名是双胞胎或三胞胎。专家 工作组(WGS)使用经过验证的方法设计了协议，以评估、扫描和维护这一队列 高留存率。这项研究通过新的实时评估补充了经过充分验证的标准化评估 目的在自然环境中无线采集数据，安全地获取青少年行为指标。 这些技术增加了测量精度、生态有效性，并有机会揭示以前 行为、生理和环境因素在心力衰竭的发展和波动中的未知影响 物质使用、屏幕媒体使用、心理和身体健康问题、大脑发育及其动态 两性关系。生物测定(例如，来自头发、脱落牙齿、血液和口腔液体)提供全基因组基因分型， 青春期荷尔蒙，更准确地估计暴露于滥用物质和环境毒素中，以及 最终对相关的表观遗传效应进行更全面的估计。最先进的和声方法 使MRI和其他数据能够跨站点无缝集成到一个无价的开放科学数据库中 在数据收集的一年内，这些数据就可以提供给更大的科学界。协调 中心(CC)达到了以前的所有目标，这里描述了它将如何实现调整后的一组目标 接下来的7年。具体地说，我们描述了为管理研究而创建的灵活的组织框架 这在很大程度上依赖于跨学科的知识和丰富的专家评估研究经验。 工作组和战略规划小组，以及CC、数据分析、信息学和 资源中心(DAIRC)和NIH协调内部和外部沟通；支持和集成 WGS执行的协议和数据质量审查的制定和修订；建立、监测和 维护各联合体场地研究方案的标准化；衡量和审查研究进展 实现保留率、数据质量和科学影响力的目标；根据这些指标，采取支持性和 采取纠正行动，确保实现目标；管理生物伦理政策和财团与 单一内部审查委员会(SIRB)；促进不同初级调查人员的专业发展；建立 解决协调委员会内部或更广泛联合体内的冲突的框架；并负责任地解决任何 意外的科学、方法、后勤或伦理挑战，以确保研究实现其 首要目标。我们还描述了CC和DAIRC如何共同实施质量控制 提高所有数据类型的数据质量的程序；与 NIMH数据档案；管理利用新的评估技术加强研究的渠道；以及 促进对zu xun数据的严格分析，为使用这一强大但复杂的数据设置新标准 以及具有挑战性的高维度研究。

PROJECT SUMMARY In its initial funding period, the ABCD consortium used a rigorous epidemiological approach to recruit a diverse sample of 11,878 9- to 10-year-olds through our 21 research sites, of which 2,136 are twins or triplets. Expert workgroups (WGs) designed protocols using proven methods to assess, scan, and maintain this cohort with very high retention rates. The study complements well validated standardized assessments with novel real-time objective data collected wirelessly in the natural environment to securely capture indices of youth behaviors. These technologies add measurement precision, ecological validity, and an opportunity to reveal previously unknown effects of behavioral, physiological, and environmental factors in the development and fluctuation of substance use, screen media use, mental and physical health concerns, brain development, and their dynamic relationships. Bioassays (e.g., from hair, shed teeth, blood, and oral fluid) provide genome-wide genotyping, pubertal hormones, more precise estimates of exposures to substances of abuse and environmental toxins, and eventually more comprehensive estimates of relevant epigenetic effects. State-of-the-art harmonization methods for MRI and other data enable seamless data integration across sites into an invaluable open-science database that becomes available to the larger scientific community within a year of data collection. The Coordinating Center (CC) met all of its previous aims, and here describes how it will achieve an adjusted set of aims for the next 7 years. Specifically, we describe a flexible organizational framework created for management of the study that relies heavily on cross-disciplinary knowledge and extensive research experience of expert assessment WGs and strategic planning groups, and a dedicated team within the CC, Data Analysis, Informatics and Resource Center (DAIRC), and NIH to coordinate internal and external communications; support and integrate the development and revision of protocols and data quality reviews performed by WGs; establish, monitor, and maintain the standardization of study protocols across the consortium sites; measure and review study progress toward goals for retention, data quality, and scientific impact; based on these metrics, take supportive and corrective action to ensure that the goals are met; manage bioethics policies and consortium interactions with the single IRB (sIRB); promote the professional development of diverse junior investigators; establish a framework to resolve conflicts within the CC or within the wider consortium; and responsibly address any unanticipated scientific, methodological, logistical, or ethical challenges to ensure the study achieves its overarching objectives. We also describe how the CC and DAIRC will together implement quality control procedures to improve data quality across all data types; coordinate data sharing functions with the staff of the NIMH Data Archive; manage a pipeline for enhancing the study with novel assessment technologies; and facilitate rigorous analyses of ABCD data that set new standards for use of data from this powerful, but complex and challenging, high-dimensional study.