ALS Efficiently Networking Advanced Beam Line Experiments (ALS-ENABLE)

摘要/Abstract 本提案的总体目标是为研究界提供一个综合的、有效的同步加速器结构生物学资源。该资源名为ALS-ENABLE，将位于加州伯克利的高级光源（ALS）。它将为ALS的成熟结构生物学技术提供一个透明的界面，并旨在优化常规和具有挑战性的问题的成功结构确定的机会。将提供多种访问机制，包括现场、远程、邮寄和协作，并将指导用户通过最适当的途径回答其生物学问题。该资源将利用其他供资机构、工业界和学术界在建设和运营方面的大量投资。该资源有3个技术操作核心（TOC），以满足研究界的特定需求：1）快速响应晶体学，2）高质量和高通量小角度X射线散射，3）专业晶体学。一个多方面的培训和推广方案将包括面对面的培训、远程和在线材料以及培训小组。该资源将有一个强大的网络存在，在同行评审的出版物中代表，并参加专业会议和研讨会，以促进ALS-ENABLE能力，招募新用户，并向更大的结构生物学社区报告资源技术。该资源将由一个管理核心管理，该管理核心将确保为同行评审的射束时间提案保持本地、远程和协作访问。基于对指标和用户反馈的评估，我们将通过ALS-ENABLE门户网站和实验资源不断改善用户交互。

Overall Summary/Abstract The overall goal of this proposal is to provide an integrated, efficient synchrotron structural biology Resource to the research community. This Resource, called ALS-ENABLE, will be located at the Advanced Light Source (ALS) in Berkeley, California. It will provide a transparent interface to the mature structural biology technologies at the ALS, and be designed to optimize the chances of successful structure determination for both routine and challenging problems. Multiple access mechanisms, including on site, remote, mail-in and collaborative, will be provided, and the users will be guided through the most appropriate routes for answering their biological question. The Resource will leverage the substantial investment in construction and operations by other funding agencies, industry and academia. The Resource has 3 Technology Operations Cores (TOCs) that address specific needs in the research community: 1) rapid response crystallography, 2) high quality and high throughput small angle X-ray scattering, and 3) specialized crystallography. A multifaceted training and outreach program will incorporate face-to-face training, remote and online materials, and training groups. The Resource will have a robust web presence, be represented in peer-reviewed publications, and participate in professional meetings and workshops to promote ALS-ENABLE capabilities, recruit new users, and report Resource technologies to the greater structural biology community. The Resource will be managed by an administrative core, which will ensure that local, remote, and collaborative access is maintained for peer-reviewed beamtime proposals. Based on evaluation of metrics and user feedback, we will consistently improve the user interactions through the ALS-ENABLE web portal and the experimental resources.