Training Program In Cellular and Molecular Medicine

项目摘要/摘要 细胞和分子医学(CMM)培训计划的任务是为博士科学家做好准备 在细胞和分子水平上的实验室研究对理解有直接影响的主题， 人类疾病的诊断、治疗和预防。通过一系列量身定做的课程，小组 讨论，个性化的临床暴露和实验室研究，该项目的博士生将 接受严格的科学研究培训，对人类生物学和人类有透彻的了解 疾病。与强调转化性研究一致，大多数CMM教员都在临床环境中工作， 分布在约翰·霍普金斯大学医学院的22个临床和基础科学系和4个研究所 医学院和公共卫生学院。培训师将接受导师培训，并接受严格的评估 根据优秀、指导能力和项目适合性的标准。目前计划规模为121名教职员工和 115名学生通过积极的导师招聘、续签和培训过程维持约1：1的师生比例 人员流动，以确保为博士候选人提供最佳的培训环境。一项全面的评估将招收20-24名学员 从约150名符合培训资助资格的候选人的稳健池规模，最近增加了40%，通过 在基于证据的决定取消GRE后，代表人数不足的少数族裔申请翻了一番 要求。培训计划将利用机构资金支付所有年份的学费，支持 行政管理和所有项目活动，并保证学员的支持。第一年的课程将从 结合人体解剖的人体精讲课程， 虚拟组织学实验室，课堂和电子讲座，以及学生的小组报告。遵循一门基础科学 课程包括分子生物学、遗传学、生物化学和细胞生物学原理，并附有 三个为期10周的实验室轮换，这一年将以临床研究和细胞和 疾病的分子基础，涵盖人类临床和/或社会相关疾病的一系列 身体，完成了一年中从书本到长凳再到床边的循环。其他计划特定的活动将 包括授予写作工作坊、新开发的研究的严谨性和再现性(3R)课程以及 在临床协作指导下的个性化床边和床后(3B)临床体验 3-4年级的导师。该项目赞助了年度务虚会、期刊俱乐部和学生运行的研究 进展研讨会系列。在教学和非学术领域有组织的职业培训机会 (选项)被纳入课程要求，毕业生从事不同的研究职业，包括 学术人员(20%)、工业(31%)、内科科学家(19%)、政府(6%)、商业、政策或AS 博士后研究员。流失率很低(5.5%)，毕业前的平均时间为5.7年。总而言之， CMM拥有创新研究生教育的经验、资源和人才，并为生物医学提供 拥有博士毕业生的劳动力经过严格培训，以满足当前和未来的需求。

PROJECT SUMMARY/ABSTRACT The mission of the training program in Cellular and Molecular Medicine (CMM) is to prepare Ph.D. scientists for laboratory research at the cellular and molecular level on topics with a direct impact on the understanding, diagnosis, treatment and prevention of human diseases. Through a series of tailored courses, small group discussions, individualized clinical exposure and laboratory research, Ph.D. candidates of this program will receive a rigorous training in scientific research and a thorough knowledge of human biology and human diseases. Consistent with the emphasis on translational research, most CMM faculty work in clinical settings, distributed over 22 clinical and basic science departments and 4 institutes within the Johns Hopkins School of Medicine and School of Public Health. Trainers will receive mentor training and are rigorously evaluated according to criteria of merit, mentorship ability and program fit. The current program size of 121 faculty and 115 students maintains ~ 1:1 faculty-student ratio by an active process of mentor recruitment, renewal and turnover to ensure the best training environment for Ph.D. candidates. A holistic review admits 20-24 trainees from a robust pool size of ~150 training grant eligible candidates, which recently increased by 40% with a doubling of underrepresented minority applications following an evidence-based decision to remove the GRE requirement. The training program will leverage institutional funds to defray tuition charges in all years, support administration and all program activities and guarantee trainee support. The first year curriculum will begin with the intensive Introduction to Human Body course that combines hands-on dissection of the human cadaver, virtual histology labs, in-class and e-lectures, and group presentations by students. Following a basic science curriculum covering principles in molecular biology, genetics, biochemistry and cell biology, accompanied by three 10-week laboratory rotations, the year will end with Introduction to Clinical Research and Cellular and Molecular Basis of Disease that covers a spectrum of clinically and/or socially relevant disorders of the human body, completing the cycle of the year from "book to bench to bedside". Other program-specific activities will include a Grant Writing workshop, a newly developed Rigor and Reproducibility in Research (3R) course and an individualized Bench to Bedside and Back (3B) clinical experience under the direction of a clinical co- mentor in years 3-4. The program sponsors an Annual Retreat, journal club and student-run research in progress seminar series. Structured career training opportunities in teaching and non-academic tracks (OPTIONS) are built into the curriculum requirements and graduates pursue diverse research careers including academic faculty (20%), industry (31%), physician scientists (19%), government (6%), business, policy or as postdoctoral fellows. Attrition rates are low (5.5%) and time to graduation has averaged 5.7 years. In summary, CMM has the experience, resources and talent to innovate in graduate education and supply the biomedical workforce with Ph.D. graduates rigorously trained to meet current and future needs.