Native Alzheimer's Disease Resource Center for Minority Aging Research (NAD-RCMAR)

总体摘要 美国印第安人/阿拉斯加原住民(AI/ANS)和夏威夷原住民/太平洋岛民(NHPI)越来越多 关注阿尔茨海默病和相关痴呆症(ADRD)，因为这些情况将有一个主要的 对他们的社区产生影响。尽管AI/ANS和NHPI在文化上是多样化的，并且分散在 在美国，他们都有很高的ADRD风险因素。此外，人工智能/人工智能和NHPI的预期寿命 在过去的50年里，他们的进步多达30年，导致他们的人口份额增加了两倍 65岁及以上。感知的需求、高风险和有限的数据促使我们提出 少数民族老龄化研究中的本土阿尔茨海默病相关资源中心(NAD-RCMAR)。我们的研究 团队提供独特的科学资源和机会，以及广泛的学术和 社区伙伴关系。总部设在华盛顿州立大学(WSU)，与斯坦福大学的合作者 和科罗拉多大学，我们将创建一个创新的项目，以了解、干预和缓解 AI/ANS和NHPI经历的与ADRD相关的健康差距。该中心的主题将强调 AI/An和NHPI健康差距以及从个人到人口层面的老龄化。我们的研究性教育 Component将资助由被称为RCMAR科学家的职业早期调查人员领导的有价值的飞行员研究。 RCMAR科学家将接受方法、测量和研究设计方面的指导和培训，以满足 高科学标准和文化上的适宜性。他们还将在以下方面得到指导 成功的资助建议，以便他们能够在ADRD研究中追求独立的职业生涯。值得注意的是，13 AI/AN或NHPI的专业人员将作为协查人员、顾问或RCMAR参与 科学家。我们的具体目标是：1)建设基础设施，整合资源，提供科学专业知识 通过指导有前途的初级和中层研究人员来增强老龄化研究队伍的多样性 在ADRD研究中持续从事研究的代表不足的少数族裔科学家，专注于人工智能/AN和NHPI 人口；2)招募RCMAR科学家，特别是具有AI/AN、NHPI和其他URM背景的科学家 开展关于ADRD的社会、行为、流行病学和临床科学的试点研究，并使用这些 将试点研究作为提供导师和职业指导的工具；以及3)促进在可持续发展和可持续发展方面取得进展 研究和增加独立的、代表性不足的少数群体研究人员的人数，重点是 AI/AN和NHPI卫生教职员工，他们可以解决AI/AN和NHPI长老的健康和福祉，健康 差异，以及从个人到社会层面的老龄化。NAD-RCMAR还将利用国家 由Buchwald博士和Manson博士创建并由AI/AN研究人员领导的卫星中心网络。这些卫星 中心将确保我们的努力是全国性的，特别是我们对RCMAR科学家的招聘，我们的 在AI/ANS和NHPI中确定与ADRD相关的数据集，以及我们对结果的传播。这项工作将 帮助解决NIA在代表不足的少数群体中研究ADRD的优先事项，如2012年所阐明的 应对阿尔茨海默氏症的国家计划。我们的中心响应了NIA对使科学研究多样化的兴趣 劳动力。

OVERALL ABSTRACT American Indians/Alaska Natives (AI/ANs) and Native Hawaiians/Pacific Islanders (NHPIs) are increasingly concerned about Alzheimer’s disease and related dementias (ADRD), as these conditions will have a major impact on their communities. Although AI/ANs and NHPIs are culturally diverse and dispersed throughout the US, they share a high prevalence of ADRD risk factors. In addition, life expectancies for AI/ANs and NHPIs have improved over the last 50 years by as much as 30 years, resulting in a tripling of their population share of people aged 65 and older. The confluence of perceived need, high risk, and limited data motivates us to propose a Native Alzheimer’s Disease-related Resource Center in Minority Aging Research (NAD-RCMAR). Our research team offers unique scientific resources and opportunities as well as an extensive network of academic and community partnerships. Based at Washington State University (WSU), with collaborators at Stanford University and the University of Colorado, we will create an innovative program to understand, intervene on, and mitigate the ADRD-related health disparities experienced by AI/ANs and NHPIs. The Center’s theme will emphasize AI/AN and NHPI health disparities and aging from the individual to the population level. Our Research Education Component will fund meritorious Pilot Studies led by early-career investigators known as RCMAR Scientists. RCMAR Scientists will receive mentorship and training in methods, measurements, and study designs that meet high scientific standards and are culturally appropriate. They also will be mentored in the development of successful funding proposals so that they can pursue independent careers in ADRD research. Notably, 13 professionals who are either AI/AN or NHPI will participate as Co-Investigators, Consultants, or RCMAR Scientists. Our Specific Aims are to: 1) Build infrastructure, assemble resources, and provide scientific expertise to enhance the diversity of the aging research workforce by mentoring promising junior and mid-level underrepresented minority scientists for sustained careers in ADRD research, focusing on AI/AN and NHPI populations; 2) Recruit RCMAR Scientists, especially those of AI/AN, NHPI, and other URM backgrounds, to conduct Pilot Studies in the social, behavioral, epidemiological, and clinical sciences on ADRD, and use these Pilot Studies as a vehicle for delivering mentorship and career guidance; and 3)Promote advances in ADRD research and increase the number of independent underrepresented minority researchers, with an emphasis on AI/AN and NHPI health faculty, who can address the health and well-being of AI/AN and NHPI elders, health disparities, and aging from the individual to the societal level. NAD-RCMAR will also capitalize on the national network of Satellite Centers created by Drs. Buchwald and Manson and led by AI/AN researchers. These Satellite Centers will ensure that our efforts are national in scope, especially our recruitment of RCMAR Scientists, our identification of datasets relevant to ADRD in AI/ANs and NHPIs, and our dissemination of results. This work will help address NIA’s research priorities for ADRD among underrepresented minorities, as articulated in the 2012 National Plan to Address Alzheimer's Disease. Our Center responds to NIA’s interest in diversifying the scientific workforce.