Electrophysiology Platform for Ion-channel Characterisation

离子通道是普遍存在的成孔膜蛋白，人类基因组编码&gt；300离子通道。离子通道的不同作用包括动作电位的产生，控制跨分泌和上皮细胞的离子流动，以及调节细胞体积、运动和增殖。药物调节剂是探测离子通道功能的有力工具，但对于大多数通道来说，这些工具是缺乏的。因此，本项目的目标是利用一个集成的体外/体内电生理平台开发第一个全面的离子通道调节器工具箱。这些药理工具将免费提供给澳大利亚研究界，用于探索离子通道的机制和生理功能。

Ion channels are ubiquitous pore-forming membrane proteins, with the human genome encoding >300 ion channels. The diverse roles of ion channels include action potential generation, control of ion flow across secretory and epithelial cells, and regulation of cell volume, motility and proliferation. Pharmacological modulators are powerful tools for probing ion channel function, but for most channels these tools are lacking. Thus, this project aims to develop the first comprehensive toolbox of ion channel modulators using an integrated in vitro/in vivo electrophysiology platform. These pharmacological tools will be made freely available to the Australian research community for probing the mechanism and physiological function of ion channels.