MULTIETHNIC/MINORITY COHORT STUDY OF DIET AND CANCER

这个项目将调查饮食和其他生活方式的危险因素。 治疗癌症。具体地说，它将：1)建立一个庞大的、多民族的 队列(包括几个亟需研究的少数群体) 将允许我们测试与饮食和饮食相关的各种假设 其他危险因素；以及2)遵循癌症发病率队列，如 以及其他慢性病。已经进行了大量的工作 已经朝着这些目标实现了。一个自我管理的 已经开发了具有主要膳食成分的调查问卷，并 预先测试过的。此外，一项涉及6,000封邮件的试点研究 随机选择的个人(代表包括的4个民族 在本提案中)产生了52.3%的总体应答率， 论证了该项目的可行性。 这项研究将包括为期两年的问卷邮寄，以 年龄在45-79岁之间的男性和女性，从四个民族中随机选择 (黑人、西班牙裔、日本人和非西班牙裔白人)，以便获得 总共有327,020个儿子。除了定量饮食之外 历史，调查问卷将包括背景信息以及 医疗、药物、体力活动和女性生殖 历史。驾照文件将提供采样帧，以及， 根据试点的结果，将产生一个参与者小组， 在特定营养素的食物来源上存在显著差异 不同族群之间的营养摄入量不同，每个族群的营养素摄入量范围也很大。 监测将在第三年开始，利用计算机连接 以人口为基础的夏威夷和加利福尼亚州的肿瘤 登记，以及与受试者的直接接触。在4-5年的时间里 对队列的随访，几种癌症的发病病例数量 网站将足以在数据分析中解决主要饮食问题 假设。 该项目的优势包括设计前瞻性、规模大、 种族多样性、少数群体构成、从 一般人口、食物来源和摄入范围的变化 营养素，开发工作已经完成。调查结果 应对未来的初级预防做出重大贡献 癌症。

This project will investigate dietary and other lifestyle risk factors for cancer. Specifically, it will: 1) establish a large, multiethnic cohort (including several minority groups much in need of study) which will allow us to test a variety of hypotheses related to dietary and other risk factors; and 2) follow the cohort for incidence of cancer, as well as other chronic diseases. A substantial amount of work has already been accomplished towards these goals. A self-administered questionnaire, with a major dietary component, has been developed and pre-tested. In addition, a pilot study that entailed mailouts to 6,000 randomly selected individuals (representing the 4 ethnic groups included in this proposal) yielded an overall response rate of 52.3%, demonstrating the feasibility of the project. The study will consist of questionnaire mailings over a 2-year period to men and women aged 45-79, randomly selected from the four ethnic groups (blacks, Hispanics, Japanese, and Nonhispanic whites), in order to obtain a total cohort of 327,020 sons. In addition to a Quantitative diet history, the questionnaire will include background information as well as medical, medication, physical activity, and female reproductive histories. Drivers' license files will provide the sampling frame, and, based on the results of the pilot, will yield a participant group with notable differences in the food sources of particular nutrients among ethnic groups and a wide range of nutrient intakes within each group. Surveillance will begin in the third year, utilizing computer linkages with the population-based Hawaii and California statewide tumor registries, and direct contact with the subjects. After 4-5 years of follow-up on the cohort, the number of incident cases for several cancer sites will be adequate to address in the data analysis the major dietary hypotheses. Strengths of this project include its prospective design, large size, ethnic diversity, minority component, selection of subjects from the general population, variation in food sources and range of intake of nutrients, and the developmental work already completed. The findings should contribute significantly to the future primary prevention of cancer.