RISK FACTORS IN EARLY HUMAN ATHEROGENESIS

这个合作项目将收集动脉和风险因素 1400例15-34岁青年创伤死亡资料 在验尸官的实验室里进行尸检。数据将是 分析不能确定成人危险因素之间的联系 动脉粥样硬化性疾病的各种病变的动脉粥样硬化 出现在这个年龄段。这些案例将补充1800个案例 在正在进行的病理生物学研究中收集到的 青年动脉粥样硬化的决定因素。该计划的主要目的 其他案件是：(1)获得足够数量的妇女案件； (2)增强研究发现风险关联的能力 病变隆起的因素，开始出现在这个年龄段；以及 (3)提高检测动脉粥样硬化遗传效应的能力。 主动脉和冠状动脉病变的测量是通过目测和 通过大体和组织学形态计量学和计算机图像分析。 风险因素测量包括胆固醇和脂蛋白胆固醇 死后血清的浓度；死后血清中的硫氰酸盐 吸烟的标志；按肾动脉壁厚度计算的血压 和小动脉；肝脏DNA多态性分析 DNA案例收集在#年参与中心进行 与当地法医合作；动脉、血液、 肝脏和其他组织在中央实验室进行，数据 由一个统计中心管理。 路易斯安那州立大学医学中心的研究单位 (LSUMC)将1.通过大体病理学和化学技术描述 确定动脉粥样硬化病变的特征，观察病变情况。 2.确定测量的经典风险因素之间的关系 死后，通过应用以下方法对动脉粥样硬化病变进行处理：a) 通过测量肾小动脉的变化来估算血压 结合心脏重量；b)估计血清胆固醇、高密度脂蛋白胆固醇、 ApoA-1、apoB和Lp(A)水平；c)区分吸烟者和不吸烟者 通过测量硫氰酸盐水平；d)通过以下方式评估糖尿病状况 糖化血红蛋白的测量；e)估计膳食和 代谢因素通过对脂肪组织脂肪酸的评估。3. 确定可能有助于理解黑白的标记， 男性和女性在动脉粥样硬化发生发展上的差异。本研究 应提供有关协会的详细数量信息 在这个重要的年龄段，动脉病变的危险因素。

This collaborative project will collect arteries and risk factor data from 1400 young persons 15-34 years of age who die from trauma and are autopsied in medical examiners' laboratories. The data will be analyzed t determine the associations of the risk factors for adult atherosclerotic disease with the various lesions of atherosclerosis which appear during this age period. These cases will supplement 1800 cases that are being collected in the ongoing study Pathobiological Determinants of Atherosclerosis in Youth. The major purposes of the additional cases are to (1) obtain an adequate number of cases of women; (2) increase the power of the study to detect associations of risk factors with raised lesions, which begin to appear in this age group; and (3) increase the power to detect genetic effects on atherosclerosis. Aortic and coronary artery lesions are measured by visual estimation and by gross and histologic morphometry using computerized image analysis. Risk factor measurements include cholesterol and lipoprotein cholesterol concentration in postmortem serum; thiocyanate in postmortem serum as a marker for smoking; blood pressure by wall thickness of renal arteries and arterioles; and DNA polymorphism by analysis of liver DNA. Collection of cases is performed at participating centers in cooperation with local medical examiners; processing of arteries, blood, liver, and other tissue is carried out in central laboratories, and data are managed by a statistical center. The research unit at Louisiana State University Medical Center (LSUMC) will 1. Describe, by gross pathology and chemical techniques, the atherosclerotic lesions to determine characteristics of lesions observed. 2. Determine relationships of classical risk factors, as measured postmortem, to atherosclerotic lesions by applying methods to: a) estimate blood pressure through measurements of renal arteriolar changes in conjunction with heart weight; b) estimate serum cholesterol, HDL-C, apoA-1, apoB and Lp(a) levels; c) differentiate smokers and non-smokers by measuring thiocyanate levels; d) evaluate diabetic status through measurements of glycosylated hemoglobin; e) estimate dietary and metabolic factors through evaluation of adipose tissue fatty acids. 3. Determine markers which may help in understanding white-black, male-female differences in development of atherosclerosis. This study should provide detailed quantitative information concerning association of risk factors with arterial lesions in this important age group.