ENVIRONMENTAL EXPOSURES IN CANCER ETIOLOGY

描述：(改编自申请者的描述)这个项目是 关注鼻咽癌和肝细胞癌的流行病学。余博士将实施和 完成一项针对60,000名45岁中国人的队列研究--在新加坡。 其主要目的是明确地建立因果关系 摄入中国咸鱼等食物与鼻咽癌的关系 与以前的病例对照研究所建议的进展情况相同。更宏大的目标 是建立一个稳定的队列，用于长期研究 饮食和其他环境决定因素与癌症和 其他慢性病。其他与NPC相关的项目包括病例对照 上海(中等风险地区)的研究及病例对照研究 在台湾(一个中等高危地区)。这两项研究是 申请者继续尝试用中文定义鼻咽癌病因学 其发病率相差20倍。申请者也将继续 她与生物化学家Steven Tannenbaum和Joseph博士的合作 兰道夫，为了系统地寻找致癌化合物(S) 导致人类鼻咽癌的中国咸鱼。未来的研究方向 肝癌病因学将主要涉及一项关于#年中年男性的队列研究。 上海(高危人群)与黑人和老年人的病例对照研究 洛杉矶县的白人居民(低风险人群)。目标是 这两项研究都是为了阐明人的独立和相互作用的作用 乙肝病毒(乙肝)、丙型肝炎病毒(丙型肝炎)、酒精和烟草 肝细胞癌的发病机制。上海的研究还有一个额外的目标： 探讨膳食黄曲霉毒素在肝癌发生中的作用 洛杉矶的这项研究还旨在检查 激素的使用与肝细胞癌的发生。

DESCRIPTION: (Adapted from the Applicant's Description) This project is concerned with the epidemiology of NPC and HCC. Dr. Yu will implement and complete a cohort study of 60,000 Chinese aged 45-64 years in Singapore. The primary aim is to definitively establish the causal relationship between ingestion of Chinese salted fish and similar foods and NPC development as suggested by previous case-control studies. A broader aim is to establish a stable cohort for the long term study of the relationship of dietary and other environmental determinants to cancer and other chronic diseases. Other NPC related projects include a case-control study in Shanghai (an intermediate risk region) and a case-control study in Taiwan (a moderately high risk region). These two studies are a part of the applicant's continuing attempt to define NPC etiology in Chinese in whom incidence rates vary by 20-fold. The applicant will also continue her collaboration with biochemists, Drs. Steven Tannenbaum and Joseph Landolph, to systematically search for the carcinogenic compound(s) in Chinese salted fish that give rise to NPC in humans. Future research in HCC etiology will mainly involve a cohort study of middle-aged men in Shanghai (a high risk population) and a case-control study among black and white residents of Los Angeles County (a low risk population). A goal of both studies is to elucidate the independent and interactive roles of hepatitis B virus (HBV), hepatitis C virus (HCV), alcohol, and tobacco in the pathogenesis of HCC. The Shanghai study has the additional goal of investigating the role of dietary aflatoxin in hepatocarcinogenesis while the Los Angeles study also aims to examine the relationship between hormone use and HCC development.