DEVELOPING AND IMPROVING INSTITUTIONAL ANIMAL RESOURCES

三角研究所(RTI)从事广泛的 涉及使用活的脊椎动物的研究活动。当前 研究项目包括毒理学、畸形学、 异源物质的代谢、药代动力学、繁殖和 生育力(包括评估化学物质对生育力的影响和 有效避孕药物的开发)、免疫学、方法 更好地提供药物，包括使用可生物降解的聚合物 植入物以及化学品和x射线的诱变效应的评估 在老鼠身上。这些项目是在一家动物研究机构进行的 它在1987-1088年进行了翻新，以使其符合 更严格的标准与进行毒理学和 致癌研究。RTI是由AAALAC认证的，必须满足其 要求以及美国农业部的要求。此外，RTI还受 小灵通《实验室护理和使用指南》中列出的要求 此外，RTI在FDA和EPA的领导下进行了大多数动物研究 良好的实验室操作规范，对于以下方面非常严格 对动物环境的控制、监测和记录 学习。目前的动物研究设施在1987-1988年间扩大到 采用完整的清洁回程走廊系统，并再增加10个 动物研究房间，总费用为258万美元，其中 47万美元由美国国立卫生研究院的赠款提供。由于预算原因 由于受到限制，当时无法升级整个暖通空调系统。 目前的提案要求提供支持，以升级和扩大现有的 支持条件(温度，特别是湿度)的暖通空调系统 对于兔子(其需求不断增加)来说，需要提供 冗余，以防止有价值的实验丢失，并升级 控制和监控系统，以满足当前严格的 环境状况的维护和记录。

The Research Triangle Institute (RTI) engages in a broad spectrum of research activity involving the use of live vertebrate animals. Current research programs include the studies of toxicology, teratology, metabolism, pharmacokinetics of xenobiotic materials, reproduction and fertility, (including assessment of chemical effects on fertility and development of effective contraceptive drugs), immunology, methods for better delivery of drugs, including the use of biodegradable polymer implants, and assessment of the mutagenic effects of chemicals and x-rays in mice. These programs are being conducted in an animal research facility that was renovated in 1987-1088 in order to bring it into compliance with the more stringent standards associated with conducting toxicological and carcinogenic research. RTI is accredited by AAALAC and must meet their requirements as well as those of the USDA. In addition RTI is bound by the requirements listed in the PHS "Guide for the Care and Use of Laboratory Animals". Moreover, RTI conducts most animal studies under FDA and EPA Good Laboratory Practice regulations, which are very stringent regarding control, monitoring and documentation of the environment of animals on study. The current animal research facility was expanded in 1987-1988 to incorporate a complete clean-return corridor system and to add 10 more rooms for animal studies at a total cost of $2.58 million dollars, of which $0.47 million was provided by a grant from NIH. Due to budgetary constraints, the complete HVAC system could not be upgraded at that time. The current proposal requests support to upgrade and expand the present HVAC system to support conditions (temperature and particularly humidity) required for rabbits (for which there is an increasing demand), to provide redundancy to prevent loss of valuable experiments, and to upgrade the control and monitoring system to meet current stringent requirements for maintenance and recording of environmental conditions.