The role of central carbon metabolism in cell cycle control in bacteria

细菌是简单的有机体，但我们仍然不知道它们如何如此忠实地协调它们的生长和繁殖，一代又一代地产生可存活的新生细胞。新发现的细菌吃的食物和它们细胞分裂的第一阶段之间的联系现在提供了一个机会，阐明细菌如何“测量”它们的能量生产来控制它们的增殖。该项目将最新技术与细菌细胞分裂和代谢方面的互补专业知识相结合。这将确定整合细菌中这些基本途径的机制，这对它们的生存和引起感染的能力至关重要。

Bacteria are simple organisms, yet we still do not understand how they coordinate their growth with their reproduction so faithfully, generation after generation, to produce viable newborn cells. The new discovery of a link between the food bacteria eat and the first stage of their cell division now provides the opportunity to elucidate how bacteria 'measure' their energy production to control their proliferation. This project combines the latest technology with complementary expertise in bacterial cell division and metabolism. This should identify the mechanism that integrates these fundamental pathways in bacteria, crucial to both their survival and ability to cause infection.