RISK FACTORS IN EARLY ATHEROGENESIS

这项合作项目将收集动脉和危险因素 数据来自1400名15-34岁死于创伤的年轻人， 在法医实验室进行尸检 数据将 分析以确定成年人危险因素的相关性， 动脉粥样硬化性疾病的各种病变的动脉粥样硬化， 出现在这个年龄段。 这些病例将补充1800例 正在进行的病理学研究中收集的 青少年运动障碍的决定因素。 的主要目的 增加病例是为了（1）获得足够数量的妇女病例; (2)增加研究的力量，以检测风险的关联 在该年龄组中开始出现的隆起病变的因素;以及 (3)增加检测动脉粥样硬化遗传效应的能力。 主动脉和冠状动脉病变通过视觉估计来测量， 通过计算机图像分析的大体和组织形态学测量。 危险因素测量包括胆固醇和脂蛋白胆固醇 死后血清中的硫氰酸盐浓度 吸烟标志;肾动脉壁厚度血压 和小动脉;和DNA多态性，通过分析肝脏 DNA. 在参与中心收集病例， 与当地医疗检查人员合作;处理动脉，血液， 肝脏和其他组织在中心实验室进行， 由统计中心管理。 路易斯安那州立大学医学中心的研究单位 （LSUMC）将1。通过大体病理学和化学技术描述 动脉粥样硬化病变，以确定观察到的病变的特征。 2.确定所测量的经典风险因素的关系 死后，动脉粥样硬化病变通过应用方法：a） 通过测量肾小动脉变化估计血压 结合心脏重量; B）估计血清胆固醇、HDL-C apoA-1、apoB和Lp（a）水平; c）区分吸烟者和非吸烟者 通过测量硫氰酸盐水平; d）评估糖尿病状态， 测量糖化血红蛋白; e）估计饮食和 通过评估脂肪组织脂肪酸的代谢因素。3. 确定可能有助于理解白黑的标记， 动脉粥样硬化发展的男女差异。 本研究 应提供详细的定量信息， 动脉病变的危险因素。

This collaborative project will collect arteries and risk factor data from 1400 young persons 15-34 years of age who die from trauma and are autopsied in medical examiners' laboratories. The data will be analyzed t determine the associations of the risk factors for adult atherosclerotic disease with the various lesions of atherosclerosis which appear during this age period. These cases will supplement 1800 cases that are being collected in the ongoing study Pathobiological Determinants of Atherosclerosis in Youth. The major purposes of the additional cases are to (1) obtain an adequate number of cases of women; (2) increase the power of the study to detect associations of risk factors with raised lesions, which begin to appear in this age group; and (3) increase the power to detect genetic effects on atherosclerosis. Aortic and coronary artery lesions are measured by visual estimation and by gross and histologic morphometry using computerized image analysis. Risk factor measurements include cholesterol and lipoprotein cholesterol concentration in postmortem serum; thiocyanate in postmortem serum as a marker for smoking; blood pressure by wall thickness of renal arteries and arterioles; and DNA polymorphism by analysis of liver DNA. Collection of cases is performed at participating centers in cooperation with local medical examiners; processing of arteries, blood, liver, and other tissue is carried out in central laboratories, and data are managed by a statistical center. The research unit at Louisiana State University Medical Center (LSUMC) will 1. Describe, by gross pathology and chemical techniques, the atherosclerotic lesions to determine characteristics of lesions observed. 2. Determine relationships of classical risk factors, as measured postmortem, to atherosclerotic lesions by applying methods to: a) estimate blood pressure through measurements of renal arteriolar changes in conjunction with heart weight; b) estimate serum cholesterol, HDL-C, apoA-1, apoB and Lp(a) levels; c) differentiate smokers and non-smokers by measuring thiocyanate levels; d) evaluate diabetic status through measurements of glycosylated hemoglobin; e) estimate dietary and metabolic factors through evaluation of adipose tissue fatty acids. 3. Determine markers which may help in understanding white-black, male-female differences in development of atherosclerosis. This study should provide detailed quantitative information concerning association of risk factors with arterial lesions in this important age group.