DEVELOPMENT OF DATABASE FOR GENETIC EPIDEMIOLOGICAL STUDIES

MEDIB已开始开发、实施和记录 全面的实验室数据管理系统。这个系统将是 用于管理临床、系谱和基因分型数据 基因图谱研究。数据库格式应用于多个 数据库(其中包括青少年牙周炎、唇腭裂 和Karagener综合征)。数据库和程序将是 在Mackintosh计算机上以第四维度(4D)实施。先生。 4D寄存器开发人员George Tiller正在与MEDIB的工作人员合作 制定适当的程序和文件。已完成的 系统将整合和管理临床信息、家庭 病史和标记等位基因分型，以及提供交互 1)大量错误检查的过程2)生成格式化的 适合输入到各种连锁分析程序的文件，以及3) 提供底物清单，并用于跟踪DNA样本和细胞 由它们产生的线条。未来的影响将包括发展 1)检查遗传不亲和性和2)舍入的步骤 并禁止将等位基因大小更直接地输入数据库。

MEDIB has begun developing, implementing and documenting a comprehensive laboratory data management system. This system will be used for the management of clinical, pedigree and genotype data for gene mapping studies. The database format shall be used for multiple databases (among them, juvenile periodontitis, cleft lip and palate and Kartagener Syndrome). The databases and programs will be implemented in 4th Dimension (4D) on Mackintosh computers. Mr. George Tiller, 4D Register Developer, is cooperating with MEDIB staff to develop appropriate procedures and documentation. The completed system will integrate and manage clinical information, family histories, and marker-allele typing as well as provide interactive procedures for 1) extensive error checking 2) generation of formatted files suitable for input to various linkage analysis programs, and 3) provide primer inventories and for tracking DNA samples and the cell lines produced from them. Future effects will include developing procedures for 1) checking genetic incompatibilities and 2) rounding and banning allele sizes for more direct input into the database.