REEVALUATION OF LONG-TERM SURVIVORS WITH DILATED CARDIOMYOPATHY

1982至1988年间，国家心肺血液研究所， 美国国家过敏症和传染病研究所 临床中心进行了一项前瞻性随机试验 特发性扩张型心肌病的炎症治疗。到1992年， 经过6至9年的随访，123名患者中有67人死亡， 另有23人接受了心脏移植。剩下的 33名未移植的幸存者中，近一半没有症状。这 方案(93-CC-0096)涉及对 这33名患者，包括放射性核素电影血管造影术， 超声心动图、动态心动图监测和运动试验。 到目前为止，33名患者中有8名已经进行了重新研究。完工后， 这项研究将代表第一个前瞻性描述 特发性扩张型心肌病的长期自然病史 特征明确的转诊患者队列。客观数据 长期关注心脏大小和心功能 幸存者将允许临床医生建议新诊断的扩张 关于心肌病患者的长期前景 减刑。

Between 1982 and 1988 the National Heart, Lung, and Blood Institute, the National Institute of Allergy and Infectious Diseases, and the Clinical Center conducted a prospective randomized trial of anti- inflammatory therapy in idiopathic dilated cardiomyopathy. By 1992, after 6 to 9 years of followup, 67 of the 123 patients had died and another 23 had undergone cardiac transplantation. Of the remaining 33 nontransplanted survivors, almost half were asymptomatic. This protocol (93-CC-0096)involves noninvasive followup re-evaluation of these 33 patients, including radionuclide cineangiography, echocardiography, Holter monitoring, and exercise testing. To date, 8 of the 33 patients have been restudied. When completed, this study will represent the first prospective description of the long-term natural history of idiopathic dilated cardiomyopathy in a well-characterized cohort of referral patients. Objective data concerning cardiac size and cardiac function among long-term survivors will permit clinicians to advise newly diagnosed dilated cardiomyopathy patients regarding their prospects for long-term remission.