STATISTICAL COORDINATING CENTER FOR COLLABORATIVE CLINICAL STUDIES

该项目包括由 酋长办公室。一项主要的倡议涉及对 帕金森病(PD)的双生子登记病因学研究 国家科学院/国家研究理事会。流行的 6,000多对双胞胎中的帕金森病病例 活着的，将被确认。这项研究将评估：环境， 受影响和未受影响的成员的病史和家族史 双胞胎；以及测量疾病随时间的进展。这 该项目将调查遗传和环境贡献，并 它们与帕金森病的病因学相互作用。一项合作协议是 为这项研究的临床方面提供资金。BFSB提供的统计数据 协调和数据管理。 该项目由乔纳斯·H·埃伦伯格博士指导。与Dr. 埃伦伯格离开NINDS后，该分部继续为 对该项目的数据管理支持有限。国际分析 1994财政年度在该项目下报告的神经系统疾病调查 现已在项目ZO1 NS 02652-11 BFSB中报告，统计 合作与协商。

This project encompasses collaborative studies undertaken by the Office of the Chief. A major initiative involves the study of the etiology of Parkinson's disease (PD) using the twin pair registry of the National Academy of Sciences/National Research Council. The prevalent cases of PD in the more than 6,000 twin pairs in which both members are alive, will be identified. This study will evaluate: environmental, medical and family histories of both affected and unaffected members of the twin pairs; and measurement of progression of disease over time. This project will investigate genetic and environmental contributions and their interactions to the etiology of PD. A Cooperative Agreement was funded for the clinical aspects of this study. BFSB provided statistical coordination and data management. This project has been directed by Dr. Jonas H. Ellenberg. With Dr. Ellenberg's departure from NINDS, the Branch has continued to provide limited data management support for the project. International analytic surveys of neurological diseases reported under this project in FY 1994 are now reported in Project ZO1 NS 02652-11 BFSB, Statistical Collaboration and Consultation.