CHARACTERIZATION OF THE WHHL RABBIT LIPOPROTEIN PHENOTYPES

兽医资源计划，国家研究资源中心， 建立了渡边遗传性高脂血症(WHHL)兔 繁殖群体作为研究人员的资源。Watanabe等人。 报道称，有两种类型的WHHL兔：类型1，那些 过早的冠状动脉粥样硬化；和2型，慢性病患者 冠状动脉粥样硬化的发展。两种类型的WHHL兔都是 以高胆固醇和高甘油三酯为特征。这个 根据脂蛋白可以区分两种类型的WHHL兔 表型。 琼脂糖凝胶电泳法测定血浆脂蛋白 来自NCRR WHHL兔群体的14只兔的电泳谱。 结果表明，猪体内至少存在两种脂蛋白表型 NCRR的WHHL兔群，其中一只的特征是β-极低密度脂蛋白。 其他研究人员的发现显示了β-极低密度脂蛋白的特性 从WHHL兔身上分离到的病毒与在人类中观察到的 III型高脂血症。数据表明，有一群人 同时存在载脂蛋白E和低密度脂蛋白受体缺陷的WHHL兔。

The Veterinary Resources Program, National Center for Research Resources, has established a Watanabe hereditable hyperlipidemic (WHHL) rabbit breeding colony as a resource for investigators. Watanabe et al. reported that there are two types of WHHL rabbits: type 1, those with premature coronary atherosclerosis; and type 2, those with slow development of coronary atherosclerosis. Both types of WHHL rabbits are characterized by high cholesterol and triglyceride concentrations. The two types of WHHL rabbits can be differentiated by their lipoprotein phenotypes. Agarose gel electrophoresis was used to determine the plasma lipoprotein electrophoretic patterns of 14 rabbits from the NCRR WHHL rabbit colony. The results showed that there are at least two lipoprotein phenotypes in the NCRR WHHL rabbit colony, and one is characterized by beta-VLDL. Findings by other investigators showed the properties of beta-VLDL isolated from WHHL rabbits are similar to those observed in humans with type III hyperlipidemia. The data suggest that there is a population of WHHL rabbits with both an apoprotein E and LDL receptor defect.