Novel ultraviolet radiation filters from extreme environments

该项目旨在利用未培养的微生物来生产和表征新的紫外线辐射滤光片生物合成途径。目前的紫外线过滤化合物是有毒的和持久的。需要在各种健康和工业应用中安全使用的可生物降解的紫外线辐射滤光片。数百万年来，紫外线辐射的破坏性作用对生物体施加了选择性压力，推动了天然辐射过滤化合物的进化多样性。该项目希望通过合成生物学来表征和利用独特的高紫外线生态系统的微生物多样性，以生产具有工业和药用价值的紫外线过滤器。

This project aims to exploit uncultured microorganisms to produce and characterise novel ultraviolet radiation-filter biosynthesis pathways. Current ultraviolet radiation-filtering compounds are toxic and persistent. There is a need for biodegradable, ultraviolet radiation filters that are safe for use across a variety of health and industrial applications. Over millions of years, the damaging effect of ultraviolet radiation has exerted selective pressure on organisms that has driven the evolutionary diversity of natural radiation-filtering compounds. This project expects to characterise and harness the microbial diversity of unique high ultraviolet radiation ecosystems via synthetic biology to produce industrially and pharmacologically useful ultraviolet radiation filters.