GENETICS LABORATORY FOR TYPING NONHUMAN PRIMATES

非人灵长类动物是各种研究的非常重要的动物模型。 人类疾病。 此外，它们对以下方面越来越重要： 基因治疗等分子医学的未来发展。 是 很明显，许多涉及基因操作的临床技术， 在人类身上的转移必须首先在非人类灵长类动物身上进行测试-- 人类的近亲 这项建议的主要目的是维持和增加 遗传学实验室对非人类灵长类动物进行分型的能力， 作为研究资源，研究人员利用非人类 灵长类动物作为人类疾病的模型。 这将涉及最先进的 DNA分型和其他有用标记物的分型，如血清蛋白和 细胞同工酶 血型数据将用于确定亲子关系 并监测系谱的准确性。 基因管理将 包括制定和推荐合理的育种计划， 保持遗传变异，最大限度地减少近亲繁殖， 淘汰多余的动物。 此外，遗传数据将用于人口研究，例如 估计基因频率、基因流、遗传关系和遗传 种群内和种群间的结构。 经证实的 系谱也将用于定量遗传学研究， 与各种研究人员的合作，遗传标记将 促进表现出复杂连锁的家系的复杂连锁分析 病毒易感性等疾病。

Nonhuman primates are exceedingly important animal models for a variety of human diseases. In addition, they are becoming increasing important for the future progress of molecular medicine such as gene therapy. It is clear that many of the clinical techniques involving gene manipulation and transfer in humans will have to be tested first in nonhuman primates-- humans' nearest relatives. It is the primary objective of this proposal to maintain and to increase the capability of the genetics laboratory for typing nonhuman primates, to serve as a research resource to investigators who utilize nonhuman primates as models for human diseases. This will involve state-of-the-art DNA typing and typing for other useful markers such as serum proteins and cellular isozymes. The typing data will be used to establish paternity and to monitor the accuracy of the pedigrees. Genetic management will involve formulating and recommending rational breeding plans for maintaining genetic variation, for minimizing inbreeding, and for the culling of surplus animals. In addition, the genetic data will be used for population studies, such as estimating gene frequencies, gene flow, genetic relationships, and genetic structure within and between breeding populations. The corroborated pedigrees will be used also for quantitative genetic studies in collaboration with various researchers, and the genetic markers will facilitate complex linkage analysis of pedigrees exhibiting complex diseases such as viral susceptibility.