Electrophysiology facility for cell phenotyping and drug discovery

该项目旨在建立一个高通量、自动化的膜片钳设施，以使研究处于细胞表型和药物发现的前沿。离子通道是构成细胞功能的膜蛋白，因此是重要的药物靶点。膜片钳技术是研究细胞功能和研究离子通道功能的最有力工具。高通量的自动化膜片钳系统提供的显著进步是，它允许同时记录多达384个细胞。该项目预计将提高自动化和标准化记录质量的能力，大幅提高数据生产速度，并使更多人能够获得膜片钳技术。

This project aims to establish a high-throughput, automated patch clamp facility to enable research at the forefront of cell phenotyping and drug discovery. Ion channels are membrane proteins that underlie cell function and are therefore important drug targets. The patch clamp technique is the most powerful tool available to functionally characterise cells and study the function of ion channels. The significant advance provided by the high-throughput, automated patch clamp system is that it allows up to 384 cells to be recorded simultaneously. This project expects to enhance capacity to automate and standardise the quality of recordings, substantially increase the rate of data production, and enable greater access to patch clamp technology.