The molecular control of lymphatic vascular differentiation

该项目旨在提高我们对新血管系统如何形成以及控制这一过程的分子的理解。 淋巴管系统在液体引流、炎症、肥胖、转移和组织修复中起作用，但我们不能轻易地促进或抑制淋巴管形成。该项目旨在建立新的知识，预计将提高我们的能力，以产生干细胞应用，组织工程，组织修复和再生的淋巴管。该项目将使用斑马鱼胚胎、新的基因组数据集和新的工具来揭示这一过程的遗传控制，并将对干细胞生物学、组织工程、修复和再生产生影响。

This project aims to improve our understanding of how a new vascular system forms and the molecules that control this process. Lymphatic vasculature plays roles in fluid drainage, inflammation, obesity, metastasis and tissue repair, yet we cannot readily promote or inhibit lymphatic vessel formation. This project aims to build new knowledge that is expected to improve our ability to generate lymphatic vessels for stem cell applications, tissue engineering, tissue repair and regeneration. This project will use zebrafish embryos, new genomic datasets and novel tools to uncover the genetic control of this process, and should have implications in stem cell biology, tissue engineering, repair and regeneration.