VALDICHRO a software tool for validation of circular dichroism spectroscopic data and bioprocess quality analyses
VALDICHRO a software tool for validation of circular dichroism spectroscopic data and bioprocess quality analyses
批准号:
BB/G023476/1
负责人:
Bonnie Wallace
金额:
$14.85万
依托单位国家:
英国
项目类别:
Research Grant
财政年份:
2009
资助国家:
英国
项目状态:
已结题
起止时间:
2009 至 --
中文摘要
圆二色谱(CD)法广泛应用于蛋白质的结构、相互作用和折叠的研究。它也被工业用作检查作为药物生产的蛋白质的质量和一致性的手段。该项目将开发新的软件VALIDICHRO,作为评估CD数据质量的工具/资源,作为研究良好做法的标准测试,作为生物处理质量控制的标准测试,以及作为将在蛋白质圆二色数据库储存库中公开共享的生成数据的验证方法。
英文摘要
The method of circular dichroism (CD) spectroscopy is widely used in studies of proteins to examine their structure, interactions and folding. It is also used by industry as a means of checking quality and consistency of proteins produced as pharmaceuticals. This project is to develop new software, VALIDICHRO, as a tool/resource for assessing the quality of CD data, as a standards test of research good practice, in bioprocessing quality control, and as a validation method for data generated that will be shared publicly in the Protein Circular Dichroism Data Bank repository.
期刊论文(1)
专著(0)
科研奖励(0)
会议论文
DOI:
10.7554/elife.58593
发表时间:
2020-10-22
期刊:
eLife
影响因子:
7.7
作者:
[Sait LG, Sula A, Ghovanloo MR, Hollingworth D, Ruben PC, Wallace BA]
通讯作者:
Wallace BA
Structure/Function Drug Interaction Studies on Voltage-Gated Sodium Channels
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批准号:BB/V018035/1
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项目类别:Research Grant
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资助金额:$3.9万
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财政年份:2022
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负责人:Bonnie Wallace
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依托单位:
Binding and interactions of Brazilian toxins to voltage-gated sodium channels: The Rational Search for New Drugs
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批准号:BB/T01153X/1
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项目类别:Research Grant
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资助金额:$2.03万
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财政年份:2020
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负责人:Bonnie Wallace
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依托单位:
Bioinformatics Resources for Circular Dichroism Spectroscopy and Structural Biology: Operation, Enhancement, Curation, and New Developments
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批准号:BB/P024092/1
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项目类别:Research Grant
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资助金额:$93.79万
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财政年份:2018
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负责人:Bonnie Wallace
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依托单位:
Structure and Function of the Human 1.8 Voltage-Gated Sodium Channel Associated with Pain Sensation
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批准号:BB/R001294/1
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项目类别:Research Grant
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资助金额:$73.99万
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财政年份:2017
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负责人:Bonnie Wallace
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依托单位:
Biophysical studies of the structure/function of antimicrobial peptides and enzymes isolated from extremophile organisms
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批准号:BB/N012763/1
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项目类别:Research Grant
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资助金额:$4.51万
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财政年份:2016
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负责人:Bonnie Wallace
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依托单位:
UK-US Collaboration on Structure, Function and Dynamics of Voltage-Gated Sodium Channels
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批准号:BB/L026252/1
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项目类别:Research Grant
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资助金额:$5.46万
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财政年份:2014
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负责人:Bonnie Wallace
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依托单位:
Structure and Function of Voltage-Gated Ion Channels and their Applications for Rational Drug Design
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批准号:BB/L006790/1
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项目类别:Research Grant
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资助金额:$67.84万
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财政年份:2014
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负责人:Bonnie Wallace
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依托单位:
The Protein Circular Dichroism Data Bank, the DichroWeb Server, and ValiDichro: Data Sharing, Analysis and Standards Resources for CD Spectroscopy
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批准号:BB/J019135/1
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项目类别:Research Grant
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资助金额:$87.31万
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财政年份:2013
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负责人:Bonnie Wallace
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依托单位:
UK/Taiwan Interchange on Synchrotron Radiation Circular Dichroism Spectroscopy
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批准号:BB/L004976/1
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项目类别:Research Grant
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资助金额:$1.58万
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财政年份:2013
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负责人:Bonnie Wallace
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依托单位:
Powder Diffraction Methods for Membrane Protein Structure Determination
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批准号:BB/J020702/1
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项目类别:Research Grant
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资助金额:$14.95万
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财政年份:2012
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负责人:Bonnie Wallace
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依托单位:
An International UK-Brazil Collaboration using Synchrotron Radiation Circular Dichroism Spectroscopy to Study Protein Structure and Function
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批准号:BB/J019747/1
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项目类别:Research Grant
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资助金额:$3.49万
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财政年份:2012
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负责人:Bonnie Wallace
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依托单位:
Developing Oriented Circular Dichroism Spectroscopy as a Methodological Tool for Characterising Membrane Proteins
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批准号:BB/H023852/1
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项目类别:Research Grant
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资助金额:$15.4万
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财政年份:2011
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负责人:Bonnie Wallace
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依托单位:
Crystal structure analysis of a voltage-gated sodium channel
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批准号:BB/H01070X/1
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项目类别:Research Grant
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资助金额:$65.4万
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财政年份:2010
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负责人:Bonnie Wallace
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依托单位:
Parallel electrophysiological characterization of sodium channels
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批准号:EP/H043888/1
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项目类别:Research Grant
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资助金额:$60.97万
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财政年份:2010
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负责人:Bonnie Wallace
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依托单位:
Developing Synchrotron Radiation Circular Dichroism (SRCD) Spectroscopy Methods and Applications for Structural Biology
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批准号:BB/G530417/1
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项目类别:Research Grant
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资助金额:$5.71万
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财政年份:2009
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负责人:Bonnie Wallace
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依托单位:
Support for the Protein Circular Dichroism Data Bank and the Dichroweb Analysis Server
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批准号:BB/F010346/1
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项目类别:Research Grant
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资助金额:$54.86万
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财政年份:2008
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负责人:Bonnie Wallace
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依托单位:
Analyses of aphid sodium channels and prediction of pesticide interactions
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批准号:BB/F009143/1
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项目类别:Research Grant
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资助金额:$12.83万
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财政年份:2008
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负责人:Bonnie Wallace
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依托单位:
Fold recognition by synchrotron radiation circular dichroism spectroscopy: a new tool for structural proteomics and structural molecular biology
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批准号:BB/D008581/1
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项目类别:Research Grant
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资助金额:$34.47万
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财政年份:2006
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负责人:Bonnie Wallace
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依托单位:
Gramicidin/Lipid Co-Crystals
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批准号:8816981
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项目类别:Continuing Grant
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资助金额:$31.5万
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财政年份:1989
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负责人:Bonnie Wallace
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依托单位:
The Structure of Gramicidin, a Transmembrane Channel
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批准号:8517866
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项目类别:Standard Grant
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资助金额:$0.23万
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财政年份:1986
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负责人:Bonnie Wallace
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依托单位:
国内基金
海外基金
低辐射空间环境下商用多核处理器层次化软件容错技术研究
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批准号:90818016
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项目类别:重大研究计划
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资助金额:50.0万元
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批准年份:2008
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负责人:傅忠传
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依托单位: