CENTRE FOR SYNTHETIC BIOLOGY OF FINE AND SPECIALITY CHEMICALS

SYNBIOCHEM中心将成为英国和欧洲在精细和特种化学品及其生产方面的合成生物学卓越中心。它将为英国学术和工业研究提供一个全国性的重点，以加速合成生物学在精细和特种化学品生产中的应用，并产生新的最先进的工具来促进这种翻译。合成生物学是一门新兴的科学，它有能力在所有工业部门的可持续制造过程中改变英国和欧洲的工业格局。从大型跨国公司到大量中小型企业，英国工业在国际上处于有利地位，可以从合成生物学实验室开发的众多新技术中受益。为了加速合成生物学向精细和特种化学品市场的转化，该中心将联合来自全国各地学术机构的技术、工具和想法，在工业和科学部门之间收获协同效应，并解决在生命科学、化学和工程界面上颠覆性技术所面临的新的伦理和监管挑战。该中心将设在曼彻斯特生物技术研究所，这是曼彻斯特大学一个独特的跨学科研究中心，汇集了500多名研究人员，他们在分子生物学、化学、工程、材料和计算科学以及医学方面具有专业知识，处于合成生物学国际发展的最前沿。作为MIB的一部分，该中心将在分拆形成和将创新研究转化为工业应用方面建立长期和杰出的记录，包括与先正达、葛兰素史克、巴斯夫和壳牌等大量合作伙伴关系。该中心将以开放和包容的方式运作，以合成生物学独特的工业需求为驱动。这将使其能够利用曼彻斯特和全国合成生物学社区的科学专业知识，通过促进主要定位在技术准备水平1至3级的多个研究项目，但也包括行业驱动的学术主导的概念验证和效用验证项目，与来自行业和学术界的合作伙伴在更高的技术准备水平。该中心将在合成生物学面临的伦理和管理方面制定主要方案。通过启动负责任创新的早期对话，提供专业知识，指导和培训合成生物学创新的负责任治理，以及促进公众参与和研究界的培训，该中心将为加速利用合成生物学快速发展所产生的机会创造条件，以造福英国经济。曼彻斯特科学伦理与创新研究所的同事们将成为这项工作的核心，以减轻与这场新工业革命相关的技术风险（真实的或感知的），而曼彻斯特大学商学院将制定负责任的创新和市场分析战略，以实现随着科学进步而出现的机会。这将通过分析和促进这一多学科/多部门领域的合作发展来支持。该中心将不断灵活地响应行业合作伙伴不断发展的需求，并在整个学术领域内发展新的科学趋势。其战略目标是通过提供世界一流的物理基础设施/科学知识的“一站式访问”，推动精细和特种化学品生产朝着可持续的制造过程，将英国工业定位在利用化学品和天然产物生物合成合成生物学的前沿。

The SYNBIOCHEM Centre will be a UK and European Centre of Excellence for Synthetic Biology in relation to fine and speciality chemicals and production. It will provide a national focus that spearheads UK academic and industrial research to accelerate the application of synthetic biology in fine and speciality chemicals production and the generation of new state-of-the-art tools to facilitate this translation.Synthetic biology is an emerging science that has the capacity to transform the UK and European industrial landscape in sustainable manufacturing processes across all industrial sectors. UK industries, from large multinationals to a large number of small and medium enterprises, are internationally well positioned to benefit from the multitude of novel technologies developed in synthetic biology laboratories. To accelerate the translation of synthetic biology towards the fine and speciality chemicals market, the Centre will unite technologies, tools and ideas that emerge from academic institutions throughout the country, harvest synergies across the industrial and scientific sectors, and address the novel ethical and regulatory challenges faced by a disruptive technology at the interface of life sciences, chemistry and engineering.The Centre will be located in the Manchester Institute of Biotechnology, a unique cross-disciplinary research centre at the University of Manchester, bringing together more than 500 researchers with expertise in molecular biology, chemistry, engineering, material and computing science, and medicine at the forefront of international developments in synthetic biology. As part of the MIB, the Centre will build on a long and distinguished track record in spin-off formation and translating innovative research to industrial application, including a substantial portfolio of partnerships, e.g., with Syngenta, GSK, BASF and Shell. The Centre will operate an open and inclusive approach driven by the unique industrial needs of synthetic biology. This will allow it to harness the scientific expertise of the synthetic biology community at Manchester and throughout the country, by facilitating multiple research projects positioned primarily at the Technology-Readiness Levels 1 to 3, but also including industry-driven academic-led proof-of-concept and proof-of-utility projects with partners from industry and academia at the higher Technology-Readiness Levels.The Centre will develop major programs in the ethical and regulatory aspects faced by synthetic biology. By initiating early dialogue on responsible innovation, providing expertise, guidance and training in responsible governance of synthetic biology innovation, and promoting public engagement and training for the research community, the Centre will create the conditions for accelerated exploitation of the opportunities generated by the rapid advances in synthetic biology for the benefit of the UK economy. Colleagues at the Manchester Institute of Science Ethics and Innovation will be central to this effort to mitigate technology risks (real or perceived) associated with this new industrial revolution, while the University of Manchester Business School will develop the responsible innovation and market analysis strategies required to realize emerging opportunities as science progresses. This will be supported by analysis and stimulation of collaborative developments in this multi-disciplinary/multi-sector field.The Centre will respond continuously and flexibly to developing needs from industry partners new scientific trends across the academic landscape. Its strategic goal is to position UK industry at the forefront of the exploiting synthetic biology for chemicals and natural products biosynthesis by providing a 'one-stop access' to world class physical infrastructure/scientific knowledge that will propel fine and speciality chemicals production towards sustainable manufacturing processes.