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Understanding how a family of chloride pumps and channels are regulated

Understanding how a family of chloride pumps and channels are regulated
了解如何调节一系列氯泵和通道
批准号:
DP150100673
负责人:
Prof Michael Parker
金额:
$51.87万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Discovery Projects
财政年份:
2015
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2015-01-01 至 2019-12-31

项目摘要

项目成果

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中文摘要
翻译
这个项目研究了几乎所有生物体中都存在的氯离子通道和泵的一个主要家族是如何在分子水平上工作的,以及它是如何受到细胞内化学信号的调制的。预期的结果是展示这些基本蛋白质的一般新机制,并为理解所有生命王国的重要生理过程提供基本见解。最终,这项工作的目标是开发新型的工程蛋白质,这些蛋白质可以作为纳米技术和生物技术应用中各种分子的亚微观电子‘开关’和高度特异的传感器。
英文摘要
This project examines how a major family of chloride channels and pumps, found in nearly all organisms, works at the molecular level and how it is modulated by chemical signals from within cells. The expected outcomes are to demonstrate novel mechanisms general to these essential proteins and to provide fundamental insights in understanding vital physiological processes across all kingdoms of life. Ultimately, this work aims to lead to the development of novel engineered proteins that can act as sub-microscopic electrical 'switches' and highly specific sensors for a variety of molecules for nanotechnology and biotechnology applications.
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