PH-SENSITIVE HYDROGELS FOR DRUG RELEASE

制定pH敏感型膨胀剂的设计指南 用于药物、双分子和药物输送的控制释放系统 对转基因分子进行了研究。这些新颖的系统是 由亲水、离子、玻璃状聚合物制成，可在水中膨胀 或者生物体液。水溶性溶质扩散机理的研究 最初是玻璃状的、不断膨胀的亲水性聚合物系统 调查过了。用交联剂进行了实验研究 甲基丙烯酸羟乙酯与甲基丙烯酸、N-乙烯基-2-甲基丙烯酸共聚物 使用几种低或高的溶质的吡咯烷酮和各种丙烯酰胺 分子量。交联度和动态度的影响 研究了聚合物在溶质扩散过程中的溶胀行为。 Diffusion/dissolution/microtoming/microscopy/stress的组合 松弛实验。网格大小是通过实验确定的 平衡溶胀研究。建立了pH敏感性的数学模型 这些水凝胶的溶胀度和动态溶胀度。

Development of guidelines for the design of pH-sensitive, swelling- controlled release systems for delivery of drugs, bimolecules and genetically-engineered molecules is investigated. The novel systems are produced from hydrophilic, ionic, glassy polymers which can swell in water or biological fluids. Mechanisms of water-soluble solute diffusion through initially glassy, continuously swelling hydrophilic polymer systems are investigated. Experimental studies are performed with crosslinked copolymers of 2-hydroxyethyl methacrylate with methacrylic acid, N-vinyl- pyrrolidone and various acrylamides using several solutes of low or high molecular weight. The effect of degree of crosslinking and dynamic swelling behavior of the polymer on solute diffusion are studied with a combination of diffusion/dissolution/microtoming/microscopy/stress relaxation experiments. The mesh size is determined experimentally by equilibrium swelling studies. Models are developed for the pH sensitivity of the degree of swelling and the dynamic swelling of these hydrogels.