Rejuvenating adult stem cells

该项目旨在揭示成人干细胞（体内所有细胞的来源）代谢调节与寿命之间的密切联系。理解我们衰老的原因以及衰老是否可以预防是研究的挑战，必须首先在细胞水平上进行研究。该项目将尝试通过干扰潜在的衰老分子总开关来使衰老的干细胞恢复活力，并开发一种识别和选择年轻干细胞的方法。预计这些结果的重要性不仅在于为衰老科学提供信息，还在于组织工程、伤口愈合、胚胎学和癌症等领域。

This project aims to uncover intimate links between metabolic regulation and longevity in adult stem cells, the source of all cells in the body. Understanding why we age and whether ageing is preventable are research challenges which must be first attacked at a cellular level. This project will try to rejuvenate aged stem cells by interfering with a prospective molecular master switch of aging and also develop an approach to identify and select youthful stem cells. The results are expected to be important beyond informing the science of ageing, in the areas of tissue engineering, wound healing, embryology and cancer.