SYNTHETIC STUDIES ON COMPLEX NATURAL PRODUCTS

这项研究的主要目标是使有意义的 通过合成对有机化学和医学的贡献 具有生理活性的天然和人工有机化合物的研究 化合物，包括1.全合成和构象 海洋天然产物孢子虫毒素的分析2.合成 低聚糖及其碳的构象分析 纤维二糖、麦芽糖、人类血型等类似物 抗原和蔗糖，3.合成和构象分析 半合成聚醚类抗生素的研究进展 有机溶剂可溶的310-螺旋寡肽，5.半 人工合成的水通道蛋白作为测定局部血药浓度的工具 完整细胞上的钙离子浓度；6.对映体选择性 红曲霉毒素和刚曲霉毒素的合成。我们相信， 有机化学的力量最有效的扩展方式是 挑战复杂的系统，以及许多进展 医学在很大程度上取决于 有机化学。 发展实用高效也是我们的具体目标。 某些天然产物及其类似物的合成 具有较高的生理活动，但在 来自自然资源的可观数量。这些研究又是 预计将刺激医学的进步。

The major objective in this research is to make significant contributions to organic chemistry and medicine through synthetic studies on physiologically active natural and man-made organic compounds, including 1. the total synthesis and conformational analysis of the marine natural product palytoxin, 2. the synthesis and conformational analysis of oligosaccharides and their carbon analogues such as cellobiose, maltose, human blood group antigens, and sucrose, 3. the synthesis and conformational analysis of semi-synthetic polyether antibiotics, 4. the development of organic solvent soluble 310-helical oligopeptides, 5. semi- synthetic aequorins as a tool of the determination of local calcium concentration on the intact cells, and 6. enantioselective synthesis of saxitoxins and gonyautoxins. We believe that the power of organic chemistry is most effectively extended by challenging complex systems, and much of the progress of medicine critically depends upon the extension of the power of organic chemistry. It is also our specific objective to develop practical and efficient syntheses of certain natural products and their analogues which have high physiological activity, but are not available in appreciable amount from natural sources. These studies are again expected to stimulate the progress in medicine.