Understanding gender differences in pain: Cellular therapies for animal pain

理解疼痛的性别差异：动物疼痛的细胞疗法。该项目旨在利用分子分析、细胞技术和免疫/激素疼痛发生器，缓解动物的慢性疼痛，并为未来的人类治疗奠定基础。慢性疼痛对女性的影响大于男性。建立疼痛的基本机制，免疫信号和分子介质的作用将使真正的疼痛调节治疗能够解决男女的关键触发因素。然后，该项目将使用专门选择的干细胞分别针对男性和女性关节炎疼痛，并展示新的兽医慢性疼痛治疗方法。预期的结果是更有效的针对性别的疼痛治疗，以及实现分子分析和细胞技术的经济价值。

Understanding gender differences in pain: Cellular therapies for animal pain. This project aims to relieve chronic pain in animals and lay the foundations for future human therapies, using molecular assays, cell technologies and immune/hormonal pain generators. Chronic pain affects females more than males. Establishing the fundamental mechanism in pain, the role of immune signalling and molecular mediators will enable true pain-modifying treatments that address pivotal triggers in both genders. This project will then use specially selected stem cells separately targeting arthritic male and female pain and demonstrate novel veterinary chronic pain treatments. Expected outcomes are more effective gender-targeted treatments of pain and the realisation of economic value of molecular assays and cell technologies.