Bio-functionalised Nanomaterials for Ultrasensitive Biosensing

该提案旨在通过设计和开发基于纳米材料的系统的创新来改变我们目前检测疾病的方式。所提出的临床样品中疾病生物标志物的超灵敏检测具有非常广泛的影响，并且对于癌症和全球健康应用等多种疾病非常重要。拟议的技术将提供比当前标准测试更高的灵敏度，并将构成新一代复杂和高性能的床旁诊断平台的重大变化。他们将结合联合收割机定制工程纳米材料的先进功能特性与定制的生物分子识别化学，以创建能够快速检测极低丰度生物标志物的传感器，并通过易于解释的信号机制（例如，简单的眼睛检测颜色变化）产生定量信息。重要的是，这项工作将与临床合作伙伴密切合作，以最大限度地发挥翻译潜力。

This proposal aims to transform the way that we can currently detect disease through innovations in the design and development of nanomaterials-based systems. The proposed ultrasensitive detection of disease biomarkers in clinical samples is very broad in impact and important for diseases as diverse as cancer and global health applications. The proposed technologies will offer significantly greater sensitivity than current standard tests, and will constitute a significant step-change towards a new generation of sophisticated and high performance point-of-care diagnostic platforms. They will combine the advanced functional properties of custom-engineered nanomaterials with tailored biomolecular recognition chemistries to create sensors capable of rapidly detecting extremely low abundance biomarkers and yielding quantitative information through easily interpretable signalling mechanisms (e.g. simple by eye detection of colour changes). Importantly, the work will be performed in close collaboration with clinical partners to maximise translational potential.