Powerful new methods for the synthesis of peptides: catalytic oxidation reactions tested to the limit

化学是一门充满活力的学科，是许多不同科学进步的中心。有机化学关注的是碳在所有不同形式中的反应性，可以被视为生物体内发生的化学。化学家们一直在寻找设计和构建分子的新方法（合成化学是分子结构），这项提议描述了一种基于肽的短而强大的新方法，通过使用新的催化反应来制造有价值的化合物。肽之所以重要，是因为它们是生命过程中必不可少的氨基酸序列;我们正在尝试以一种全新的方式制造肽，这将使我们能够更好地控制我们所制造的结构的性质，这将使我们能够制造天然和非天然的肽，这些肽可以作为潜在的新药进行测试。开发和测试的极限，新的催化反应也是这个项目的核心，也是一项值得努力的工作。新催化剂和催化系统的开发和应用非常重要，因为它使化学反应更快，更清洁，废物更少：这对工业和环境都是一件好事。为了强调该提案中所述化合物的重要性，可以在销售额超过10亿美元的几种药物中发现肽。这里提出的新化学将提供一种新的，有效的和强大的方式，使肽使用催化控制官能团的掺入：这将是非常有益的学术界和工业界。我们还计划筛选具有广泛生物活性的化合物。鉴于上述所有情况，我们必须有新颖、有效和强大的方法来制备新的肽衍生物，以便我们能够研究和使用它们。

Chemistry is a dynamic subject that is at the centre of many different scientific advances. Organic chemistry is concerned with the reactivity of carbon in all its different forms and can be viewed as the chemistry taking place within living things. Chemists are constantly looking for new ways of designing and building molecules (synthetic chemistry is molecular architecture) and this proposal describes a short and powerful new way of making valuable compounds, based on peptides, by using new catalytic reactions. Peptides are important because they are the sequences of amino acids that are absolutely essential to the processes of life; we are attempting to make peptides in a fundamentally new way that will give us great control over the nature of the structures that we make and which will allow us to make natural and unnatural peptides that can be tested as potential new medicines.Developing, and testing the limits of, new catalytic reactions is also central to this project, and is also a worthwhile endeavour. The development and application of new catalysts and catalytic systems is important because it makes chemical reactions run faster, and become cleaner with less waste: this is clearly a good thing for industry and also for the environment. To underscore the importance of the compounds that feature in this proposal, peptides can be found in several drugs that have sales of over 1 billion dollars. The novel chemistry proposed here will provide a new, efficient and powerful way of making peptides using catalysis to control functional group incorporation: this will be of great benefit to both academia and industry. Plans have also been made to screen the compounds that we make for a wide range of biological activity.Given all of the above, it is imperative that we have novel, efficient and powerful methods for making new peptide derivatives so that we can study and use them.