K ALFA DUAL-ENERGY X-RAY SOURCE FOR CORONARY ANGIOGRAPHY

提出了一种用于双能减影的特征线x射线源。 人体冠状动脉小面积密度碘的成像。 该源码是基于K-Alpha的产生，在线条上旋转 高能电子束轰击金属化合物目标。在第一阶段， 不同靶构型的X射线光谱是用 蒙特卡罗电子-光子程序和双能成像模拟程序 是为了在一定范围内计算图像信噪比而开发的 碘和组织参数。计算结果表明，优化后的 系统将能够成像2毫克/平方英尺。Cm的碘造影剂 20克/平方英尺。Cm组织，SNR=5，总成像时间为10ms。在……里面 此外，第一阶段设计的X射线源的成本和尺寸为 与临床使用相容。 在第二阶段，将进行原则证明实验，以验证 拟议的x射线源的操作能力和限制。一个 将建造电子加速器原型和靶组件，并 用于对模体进行双能量减影成像实验。 将对两种探测器配置进行评估。升级的加速器和 靶标设计能够提供所需的高光子通量 这项技术的临床应用将被开发出来。

A characteristic-line x-ray source is proposed for dual-energy subtraction imaging of small areal densities of iodine in the human coronary arteries. The source is based on the production of the K-alpha, lines in a rotating metal compound target bombarded by a high energy electron beam. In Phase 1, x-ray spectra from various target configurations were calculated using a Monte-Carlo electron-photon code and a dual-energy imaging simulation code was developed to calculate image signal-to-noise ratio for a range of iodine and tissue parameters. The calculations indicate that an optimized system would be capable of imaging 2 mg/sqr. cm of iodine contrast agent in 20 g/sqr. cm of tissue with a SNR=5 and a total imaging time of 10 ms. In addition, the cost and size of the x-ray source designed in Phase I are compatible with clinical use. In Phase II, proof-of-principle experiments will be performed to verify the operating capabilities and constraints of the proposed x-ray source. A prototype electron accelerator and target assembly will be constructed and used to conduct dual-energy subtraction imaging experiments on phantoms. Two detector configurations will be evaluated. An upgraded accelerator and target design capable of providing the high photon fluxes required for the clinical implementation of this technique will be developed.