PHARMACOLOGIC REDUCTION OF ALCOHOL CONSUMPTION IN ALCOHOLIC PATIENTS

最近的研究表明，酒精消费是由几个因素调节的。 相互作用的神经递质，包括多巴胺和血清素 系统. 在随机双盲设计中，慢性酒精中毒 门诊患者接受左旋多巴或L-5-羟基色氨酸， 外周脱羧酶抑制剂卡比多巴或安慰剂治疗一年 期 在这一年里，酒精消耗，肝功能，渴望 酒精，精神状态，心理社会功能， 定期对药物进行评估。 被带进 研究中，3个月后和1年后， 用于测量药物作用：（1）行为评价;（2） 测定药物、单胺、激素和 血液和脑脊液中的肽;（3） 心率、血压和血浆去甲肾上腺素浓度;以及 (4)评估血浆加压素对盐水输注的反应。 37名患者中只有8名（22%）能够保持清醒一年。 年 服用多巴胺和5-羟色胺抑制剂， 对患者保持清醒的时间长度的统计学影响。 作为 这些戒酒一年的人， 受过高等教育多巴胺浓度降低 高血压患者的代谢物含量比复发者高。 结果是 发表在《临床药理学和治疗学》上。

Recent studies indicate that alcohol consumption is regulated by several interacting neurotransmitters, including the dopamine and serotonin systems. In a randomized double-blind design, chronic alcoholic outpatients received L-DOPA or L-5-hydroxytrytophan, both with the peripheral decarboxylase inhibitor carbidopa, or placebo for a one-year period. During this year, alcohol consumption, liver function, craving for alcohol, mental status, psychosocial functioning, and compliance with medication were assessed at regular intervals. Prior to entry into the study, after 3 months, and at one year, the following procedures were conducted to measure drug effects: (1) behavioral evaluation; (2) determination of concentrations of drugs, monoamines, hormones, and peptides in blood and cerebrospinal fluid; (3) orthostatic changes in heart rate, blood pressure, and plasma norepinephrine concentrations; and (4) assessment of plasma vasopressin response to saline infusion. Only eight (22%) of the 37 patients were able to remain sober for one year. The administration of precursers of dopamine and serotonin had no statistical effect on the length of time patients remained sober. As a group, these alcoholics who remained sober for one year had more education, higher I.G. and lower concentrations of the dopamine metabolytes, HVA, than those who relapsed. The results are being published in Clinical Pharmacology and Therapeutics.