BEHAVIORAL AND PHYSIOLOGICAL EFFECTS OF 2-DEOXYGLUCOSE INFUSIONS

2-脱氧葡萄糖(2-DG)是一种葡萄糖类似物，它竞争性地抑制 葡萄糖-6-磷酸脱氢酶并导致细胞内 葡萄糖酸化。在以前的研究中，2-DG被用作压力源 激活下丘脑-垂体-肾上腺(HPA)轴和 交感肾上腺轴和刺激食欲中枢 下丘脑。我们对这一范例的兴趣是由临床 观察到酗酒者经常摄入更多的 停止饮酒后的碳水化合物。为了探索 酒精中毒患者可能存在下丘脑异常 给戒酒者注射2-DG，并测量结果 2-DG挑战引起的行为和生理变化。我们 假设2-DG诱导的葡萄糖反应将引起 可能阐明机制的神经内分泌和行为变化 酒精在下丘脑的作用。结果分析显示， 酗酒者在服用2-DG和2-DG后摄入的卡路里比对照组少 安慰剂给药。相反，酗酒者表现出夸张的 下丘脑，促肾上腺皮质激素对葡萄糖代谢的反应。

2-deoxyglucose (2-DG) is a glucose analog which competitively inhibits glucose-6-phosphate dehydrogenase and leads to intracellular glucoprivation. In previous studies, 2-DG has been used as a stressor to activate both the hypothalamic-pituitary-adrenal (HPA) axis and the sympathetic adrenal axis and stimulate the appetitive centers of the hypothalamus. Our interest in this paradigm was generated by the clinical observation that alcoholics frequently consume increased amounts of carbohydrates following cessation of drinking. In order to explore possible hypothalamic abnormalities in patients with alcoholism, we administered 2-DG to abstinent alcoholics and measured the resulting behavioral and physiological changes arising from the 2-DG challenge. We postulated that a 2-DG induced glucoprivic response would give rise to both neuroendocrine and behavioral changes that might elucidate mechanisms of alcohol's action in the hypothalamus. Analysis of the results show alcoholics consume less calories than controls following both 2-DG and placebo administration. Conversely, alcoholics show an exaggerated hypothalamic, ACTH response to glucoprivation.