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THERAPEUTIC STUDIES IN MURINE LUPUS

THERAPEUTIC STUDIES IN MURINE LUPUS
小鼠狼疮的治疗研究
批准号：
3810923
负责人：
A D STEINBERG
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3810923
关键词：
CD4 molecule CD8 molecule antibody autoimmune disorder connective tissue disorder chemotherapy disease /disorder model genetic strain immunogenetics immunopathology chemotherapy infant animal interleukin 4 laboratory mouse leukocyte activation /transformation nonhuman therapy evaluation systemic lupus erythematosus tumor necrosis factor alpha

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中文摘要
翻译
自发自身免疫的小鼠品系为潜在的 治疗患有自身免疫性疾病的人类的新疗法。我们已经重复了一次 研究并给MRL-LPR/LPR小鼠注射了抗IL-4抗体。 出生后再次观察到发育迟缓的淋巴结病。 从2周龄开始给NZB小鼠注射抗IL5对小鼠的免疫功能无明显影响 IGM制作。
英文摘要
Spontaneously autoimmune mouse strains provide good models for potential new therapies for humans with autoimmune diseases. We have repeated a prior study and have administered anti-IL 4 antibody to MRL-lpr/lpr mice from birth and again observed retarded from the development of lymphadenopathy. Anti-IL5 given to NZB mice from 2 weeks of age had no beneficial effect on IgM production.
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会议论文
ANTINUCLEAR ANTIBODIES IN SPONTANEOUS AND DRUG-INDUCED SLE AND OTHER DISEASES
PATHOGENESIS OF AUTOIMMUNITY IN MICE WITH SLE-LIKE ILLNESS
PATHOGENESIS OF AUTOIMMUNITY IN MICE WITH SLE-LIKE ILLNESS
VARIOUS CYTOTOXIC DRUG PROGRAMS IN DIFFUSE LUPUS NEPHRITIS
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