Control of human inspiratory muscles in health and disease

该项目将研究正常健康受试者和患有呼吸系统疾病（如阻塞性睡眠呼吸暂停）的受试者如何控制将空气“泵”入肺部的人体吸气肌和上呼吸道“扩张肌”。我们将研究(i)对吸气肌的输出，（ii）自动和自愿控制呼吸的相互作用，以及（iii）人体泵肌和扩张肌的反射连接。这项工作有望对基础和病理生理学有新的认识。

This project will study how human inspiratory muscles that 'pump' air into the lungs and upper airway 'dilator' muscles are controlled in normal healthy subjects and subjects with respiratory disorders such as obstructive sleep apnoea. We will study (i) the output to the inspiratory muscles, (ii) the interation of automatic and voluntary control of breathing, and (iii) reflex connections of human pump and dilator muscles. This work promises new understanding of basic and patho-physiology.