AGE ASSOCIATED CHANGES IN VASCULAR STIFFNESS PROPERTIES

尽管正常的衰老伴随着动脉粥样硬化的增加 硬度、硬度与心脏结构的关系，以及 功能未知。这个项目的最终目标是 确定动脉僵硬特性如何影响心肌 结构和功能与预测心血管发病率和 死亡率。下面描述了几个子项目。A.确定是否 动脉僵硬本身对左侧动脉有独立的影响 左心室(LV)质量，我们从以下公式得出左心室质量指数(LVMI 超声心动图和脉搏波速度(PWV)和动脉僵硬 133例眼压平坦仪测量的眼压增大指数(AGI) 血压正常的BLSA受试者年龄为23-87岁。与年龄相关的增长是 以LVMI(r=0.24)、SBP(r=0.31)、PWV(r=0.66)为指标 经多元回归分析，AGI(p=0.004)、SBP (P&lt；0.03)和男性(p=0.04)独立，而不是年龄或PWV 预测更大LVMI.B.的指标，以测试钝化的LV排空和 老年人与年轻人的左心室射血分数对运动的反应 受试者可以通过减少中心动脉僵硬来改善，我们 9名健康受试者-82进行最大直立周期运动 管理前和管理后年龄分别为40岁和8人 血管扩张剂硝普钠(N)静脉注射使左心室收缩末期减少 在这些老年人中，峰值努力时的收缩容量(ESV)和增加的LVEF 受试者，消除上述变量中的年龄差异 我们将测试几个月的家庭有氧运动的假设 运动训练可以降低NIH赞助的动脉僵硬 对810名35-75岁的人进行了多中心试验。D.我们最近进行了 完成了一项研究，考察了年龄、钠摄入量、身体 成分和体力活动对老年人动脉僵硬和左心室重量的影响 台湾人口2人(合同编号N01-AG-02-2118)E.多中心 确定动脉僵硬是否为独立危险因素的研究 老年人自由生活的心血管事件的因素是 由流行病学人口学生物计量项目开发 一种计算NIA.F.特性阻抗的方法 无创性测量中心动脉的动脉树 压力和流量是最近发展起来的。

Although normative aging is accompanied by increases in arterial stiffness,the relationship between stiffness and cardiac structure and function is not known. The ultimate goals of this project are to determine how arterial stiffness properties influence myocardial structure and function and predict cardiovascular morbidity and mortality.Several sub-projects are described below.A.To determine whether arterial stiffness per se exerts an independent influence on left ventricular (LV) mass,we derived LV mass index (LVMI) from echocardiograms and arterial stiffness from pulse wave velocity (PWV) and applanation tonometry-derived augmentation index (AGI) in 133 normentensive BLSA subjects age 23-87 yrs. Age-associated increases were seen in LVMI (r=0.24), systolic blood pressure(SBP, r=0.31), PWV (r=0.66) and AGI (r=0.53).By multiple regression analysis, AGI (p=.004), SBP (p<.03) and male sex (p=.04) but not age or PWV were independent predictors of greater LVMI.B.To test whether the blunted LV emptying and LV ejection fraction(LVEF) response to exercise in older versus younger subjectscan be ameliorated by reducing central arterial stiffness,we performed maximal upright cycle exercise in 9 healthy subjects 64-82 years old and 8 subjects <40 years old before and after adminstering the vasodilator sodium nitroprusside (N) intravenously.N reduced LV end systolic volume (ESV) and increased LVEF at peak effort in these older subjects, eliminating age differences in these variables noted prior to N.C.We will test the hypothesis that several months of home-based aerobic exercise training can reduce arterial stiffness in an NIH-sponsored multicenter trial of 810 individuals 35-75 years old.D.We have recently completed a study examining the effect of age, sodium intake, body composition and physical activity on arterial stiffness and LV mass in 2 populations in Taiwan.(Cf Contract #N01-AG-02-2118)E.A multicenter study to determine whether arterial stiffness is an independent risk factor for cardiovascular events in elderly free-living persons is being developed by the Epidemiology Demography Biometry Program of the intramural NIA.F.A method for calculation of charteristic impedance of the arterial tree from non-invasive measurements of central arterial pressure and flow has recently been developed.