EPIDEMIOLOGIC STUDIES OF DIET AND CANCER IN HAWAII

总体目标是确定饮食风险和预防措施 癌症的因素将导致这种疾病的控制。这个 该计划利用了多民族、多文化的人口 这为开展这项研究提供了独特的机会。 在目前的赠款期间，在以下六个方面取得了实质性进展 每个项目的数据收集工作都已接近完成： 对前瞻性队列的监测；恶性肿瘤的病例对照研究 黑色素瘤、结直肠癌和子宫内膜癌.计算 四个民族的出生地发病率及其比较 有相应的饮食摄取模式；以及 基于我们经过测试的面对面的方法，对饮食历史进行电话采访。 在续约期间，我们将继续追求饮食 癌症病因学。描述了三个项目，包括：1)一个案例-- 胃癌的对照研究，将调查分开和 幽门螺杆菌感染和几次饮食暴露的交互作用； 2)基因流行病学研究，将试图区分 环境(饮食)对结肠癌风险的遗传性贡献 癌症；以及3)继续对人群队列进行被动监测 测试饮食与几个不太常见的癌症部位的关系，并 比较不同种族之间的研究结果。 这些研究在主题和方法上是相互关联的，并且 共享几个共同的核心资源，包括数据收集程序、 食品的计算机编程、营养支持和维护 成分数据库和生物统计学支持。作为一个集成的 计划，这项研究实现了省力，并促进了 调查人员之间的合作和智力互动 更有效地推进研究。

The overall objective is to identify dietary risk and protective factors for cancer that will lead to the control of this disease. The program takes advantage of the multiethnic, multicultural population of Hawaii which provides unique opportunities for conducting this research. During the current grant period, substantial progress has been made on six projects, each of which is nearing the completion of data collection: surveillance on a prospective cohort; case-control studies of malignant melanoma, colorectal cancer and endometrial cancer; computation of incidence rates by place of birth for four ethnic groups and comparison with corresponding dietary intake patterns; and the development of a telephone diet history interview based on our tested face-to-face method. For the renewal period, we will continue our pursuit of the dietary etiology of cancer. Three projects are described, including: 1) a case- control study of gastric cancer that will investigate the separate and interactive effects of H. pylori infection and several dietary exposures; 2) a genetic epidemiology study which will attempt to distinguish hereditary from environmental (dietary) contributions to the risk of colon cancer; and 3) continued passive surveillance on a population cohort to test the relationship of diet to several less common cancer sites, and to compare findings among different ethnic groups. These studies are interrelated thematically and methodologically, and share several common core resources, including data collection procedures, computer programming, nutritional support and maintenance of a food composition data bank, and biostatistical support. As an integrated program, the research achieves an economy of effort, and fosters collaborations and intellectual interactions among the investigators that advance the research more effectively.