SERUM CHOLESTEROL AND TRIGLYCERIDE VALUES OF THE NCRR WHHL RABBIT COLONY

兽医资源计划，国家研究资源中心， 建立了一个渡边遗传性高脂血症（WHHL）兔 繁殖群 作为研究人员的资源，需要使用这种动物模型， 由低密度脂蛋白引起人类家族性高胆固醇血症 受体缺陷 本项目的目的是表征血清胆固醇和 NIH WHHL兔群的甘油三酯值。 收集血液 8周、3个月、7个月和12个月时， 月龄。 分析血清中的脂蛋白胆固醇和 甘油三酯 已经开发了一个计算机程序来追踪血统 的WHHL兔，使其有可能评估的影响， 基因型对胆固醇和甘油三酯值的影响 总血清 胆固醇值范围为310至1251 mg/dl，平均值为828 mg/dl。 低密度脂蛋白（LDL）胆固醇值范围为70至80。 1185 mg/dl，平均值为630 mg/dl。 血清甘油三酯值范围 从 107至959 mg/dl，平均值为394 mg/dl。 似乎存在 血清甘油三酯浓度与性别的相关性 兔子 平均 男性和女性甘油三酯浓度分别为510 mg/dl和309 mg/dl， 分别

The Veterinary Resources Program, National Center for Research Resources, has established a Watanabe heritable hyperlipidemic (WHHL) rabbit breeding colony as a resource for investigators requiring this animal model for use in human familial hypercholesterolemia due to a low density lipoprotein receptor defect. The purpose of this project is to characterize the serum cholesterol and triglyceride values of the NIH WHHL rabbit colony. Blood was collected from WHHL rabbits at eight weeks, three months, seven months, and twelve months of age. The serums were analyzed for lipoprotein cholesterol and triglycerides. A computer program has been developed to track pedigrees of the WHHL rabbits, making it possible to evaluate the influence of genotype on cholesterol and triglyceride values. Total serum cholesterol values range from 310 to 1251 mg/dl with a mean of 828 mg/dl. The low density lipoprotein (LDL) cholesterol values range from 70 to 1185 mg/dl with a mean of 630 mg/dl. Serum triglyceride values range from 107 to 959 mg/dl with a mean of 394 mg/dl. There appears to be a correlation between serum triglyceride concentration and the sex of the rabbit. The mean male and female triglyceride concentrations were 510 mg/dl and 309 mg/dl, respectively.