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STUDIES ON THE IMMUNOBIOLOGY OF MALARIA

STUDIES ON THE IMMUNOBIOLOGY OF MALARIA
疟疾免疫生物学研究
批准号：
3768727
负责人：
L H MILLER
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3768727
关键词：
Aotus Mycobacterium bovis Plasmodium falciparum Salmonella bacterial antigens cellular immunity erythrocytes helper T lymphocyte host organism interaction intracellular parasitism malaria microorganism immunology protozoal antigen

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中文摘要
翻译
某些啮齿动物对无性红细胞寄生虫的免疫力是 依赖于依赖于CD4=T细胞的细胞介导的机制 和脾，并独立于抗体。这种豁免权可以是 由沙门氏菌和疟疾抗原诱导。目前的研究是 旨在识别那些将导致 为了保护。此外，我们正在开展测试构造的研究 在沙门氏菌和卡介苗中，这将导致对疟疾的保护 Aotus猕猴体内的恶性疟原虫。
英文摘要
Immunity to asexual erythrocytic parasites in certain rodent malaris is dependent on cell mediated mechanisms that are dependent on CD4=T cells and the spleen and are independent of antibody. Such immunity can be induced by Salmonella and malarial antigens. The present studies are designed to identify those proteins and T cell epitopes that will lead to protection. In addition, we are developing studies to test constructs in Salmonella and BCG that will lead to protection against Plasmodium falciparum in Aotus monkeys.
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会议论文
IDENTIFICATION OF RECEPTORS FOR MEROZOITE INVASION OF ERYTHROCYTES
IDENTIFICATION OF RECEPTORS FOR MEROZOITE INVASION OF ERYTHROCYTES
IDENTIFICATION OF RECEPTORS FOR MEROZOITE INVASION OF ERYTHROCYTES
IDENTIFICATION OF RECEPTORS FOR MEROZOITE INVASION OF ERYTHROCYTES
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