THERAPEUTIC TRIALS IN IDIOPATHIC INFLAMMATORY MYOPATHIES

试图找到治疗类固醇抗药性肌炎的更好方法 (除包涵体肌炎外)，我们已经进行了随机 静脉注射甲氨蝶呤与解救白血球蛋白的交叉试验 甲氨蝶呤和硫唑嘌呤的混合物。病人的应计费用是 大约完成了三分之二。 我们对这种疗法进行了两次广泛的回顾分析。 肌炎的症状。第一，超过100名患者的详细记录 回答是可用的，分析了影响 对强的松、甲氨蝶呤和硫唑嘌呤的反应。另一个是 卵巢癌对激素和细胞毒治疗的反应分析 近30例包涵体肌炎的临床分析 有史以来第一个在这种情况下进行的对照治疗试验 我们在过去的几年里进行了。这些现在已经是 出版了。

In an attempt to find a better way to treat steroid-resistant myositis (other than inclusion body myositis), we have carried out a randomized crossover trial of intravenous methotrexate with leukovorin rescue and a combination of methotrexate and azathioprine. Accrual of patients is about two-thirds complete. We have carried out two extensive retrospective analyses of the therapy of myositis. One, of well over 100 patients on whom thorough records of responses were available, was analyzed for the factors that influence the responses to prednisione, methotrexate, and azathioprine. The other was a close analysis of the responses to steroid and cytotoxic therapy in almost 30 patients with inclusion body myositis, including an analysis of the first ever controlled therapeutic trial in that condition which we carried out over the past several years. These have now been published.