SYMPATHOADRENAL AND CATECHOLAMINERGIC FUNCTION IN HEALTH AND DISEASE

我们的实验室开发并应用了评估功能的方法， 中枢和外周儿茶酚胺能系统和协调 这些系统与其他稳态系统在健康，压力， 疾病 本年度的研究成果包括：（1）位置发射断层扫描 (PET)全身给予6-[18 F]氟多巴胺后扫描 [18F]-6 F-DA提供了一种非侵入性的体内方法来检查心脏 交感神经支配和功能。(2)临床微欧元- 应用图形和示踪剂去甲肾上腺素（NE）动力学方法， 诊断神经心脏疾病，测试“肾上腺素假说”， 交感神经传递，并评估儿茶酚-胺能效应 人体内的糖皮质激素 (3)体内微透析显示， 自发性高血压大鼠的α 2-肾上腺素受体增加， 介导的儿茶酚胺生物合成和NE释放的抑制， 下丘脑后外侧(4)神经内分泌反应模式 支持了压力的稳态理论

Our laboratory develops and applies methods for assessing the function of central and peripheral catecholaminergic systems and the coordination of these systems with other homeostatic systems in health, stress, and disease. Findings this year include: (1) Position-emission tomographic (PET) scanning after systemic administration of 6-[18F]fluorodopamine ([18F]-6F-DA) provided a noninvasive, in vivo means to examine cardiac sympathetic innervation and function in humans. (2) Clinical microneuro- graphic and tracer norepinephrine (NE) kinetic methods were applied to diagnose neurocardiologic disorders, test the "epinephrine hypothesis" of sympathetic neurotransmission, and assess catechol~aminergic effects of glucocorticoids in humans. (3) In vivo microdialysis revealed juvenile spontaneously hypertensive rats have increased alpha2-adrenoceptor- mediated restraint of catecholamine biosynthesis and NE release in the posterolateral hypothalamus. (4) Patterning of neuroendocrine responses has supported a homeostat theory of stress.