课题基金 / 基金详情

VARIOUS CYTOTOXIC DRUG PROGRAMS IN DIFFUSE LUPUS NEPHRITIS

VARIOUS CYTOTOXIC DRUG PROGRAMS IN DIFFUSE LUPUS NEPHRITIS
弥漫性狼疮性肾炎的各种细胞毒性药物方案
批准号：
3792214
负责人：
A D STEINBERG
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3792214
关键词：
combination chemotherapy connective tissue disorder chemotherapy drug administration rate /duration drug adverse effect human subject human therapy evaluation immunopathology chemotherapy immunosuppressive intravenous administration kidney disorder chemotherapy longitudinal human study methylprednisolone nephritis renal failure systemic lupus erythematosus

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中文摘要
翻译
患者随机接受（i）每月IV-环磷酰胺， (ii)每月IV甲泼尼龙，或（iii）两者。该研究现已 对新进入者关闭。进展为肾衰竭的速率， 正在评估重新治疗的要求和药物毒性。 整个集团尚未出现明显的分歧， 完成3年研究的患者。
英文摘要
Patients were randomized to receive (i) monthly IV-cyclophosphamide, (ii) monthly IV methylprednisolone, or (iii) both. The study is now closed to new entrants. Rate of progression to renal failure, requirements for re-treatment, and drug toxicities are being assessed. Clear-cut differences have yet to emerge for the entire group of patients completing 3 years of study.
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会议论文
ANTINUCLEAR ANTIBODIES IN SPONTANEOUS AND DRUG-INDUCED SLE AND OTHER DISEASES
PATHOGENESIS OF AUTOIMMUNITY IN MICE WITH SLE-LIKE ILLNESS
VARIOUS CYTOTOXIC DRUG PROGRAMS IN DIFFUSE LUPUS NEPHRITIS
IMMUNE ABNORMALITIES IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS