QUANTITATIVE ANALYSIS OF VIRAL GENOMES AND THEIR CLINICAL CORRELATIONS

这是一项新启动的计划，以应对日益增长的 更精确地测量任何病毒的相关基因组信息 感染。了解特定病毒基因的存在将有所帮助 在识别感染源方面。然而，要评估一个 疾病，以评估一种治疗的疗效，以确定 疾病进展的预测器，并监测病人的 感染的进展，更准确和定量的分析 特定的基因是必需的。这些以前高度研究的 定向问题现在可以用高级语言来回答 聚合酶链式反应(PCR)等分子生物学技术， 限制性核酸酶消化片段的测序和作图。我们 会将这项技术与我们目前正在进行的 乙肝病毒、丙型肝炎病毒和艾滋病毒等临床研究 感染。我们还将改进基本的聚合酶链式反应技术，使其成为 量化程序。

This is a newly initiated program in response to the increasing demand of more precise measurement of relevant genomic information in any viral infection. The knowledge of the presence of specific viral gene will help in identifying the infectious agent. However, to assess the stage of a disease, to evaluate the efficacy of a treatment, to determine the value of a predictor in the progression of a disease and to monitor the patient's progression of an infection, a more precise and quantitative analysis of the specific gene would be required. These previously highly research oriented questions can now being to be answered with the advanced technology of molecular biology such as polymerase chain reaction (PCR), sequencing and mapping of the restriction nuclease digested fragments. We would apply this technology in conjunction with our current on-going clinical research such as hepatitis B virus, hepatitis C virus and HIV infections. We would also improve the basic PCR technique to become a quantitative procedure.