HUMAN HERPESVIRUS-6 (HHV-6), EPSTEIN-BARR VIRUS (EBV) AND HIV STUDIES

15株HHV-6分离自正常献血者、免疫缺陷患者 系统性红斑狼疮(SLE)。非典型多克隆 淋巴组织增生(APL)、白细胞减少和亚急性皮疹 可能很重要的生物学、免疫学和分子差异 用于血清流行病学和其他免疫病毒学研究。活动性HHV-6 急性早幼粒细胞白血病、艾滋病、干燥综合征患者均有感染。 霍奇金氏病、慢性疲劳综合征、系统性红斑狼疮和一些移植 患者，基于HHV-6单抗与 患者淋巴细胞、HHV-6 IgM抗体阳性和 免疫球蛋白抗体显著升高。HHV-6病毒的重新激活可能有助于 免疫紊乱，要么通过干扰免疫细胞的功能 或通过多克隆刺激T细胞，进而导致疾病 表现形式。

Fifteen HHV-6 isolates from normal donors, patients with immunodeficiency syndromes, systemic lupus erythematosus (SLE). atypical polyclonal lymphoproliferation (APL), leukopenia and Exanthum subitum revealed biological, immunological and molecular differences which may be important for seroepidemiological and other immunovirological studies. Active HHV-6 infection was observed in patients with APL, AIDS, Sjogren's syndrome. Hodgkin's disease, chronic fatigue syndrome, SLE and some transplant patients, based on reactivities of HHV-6 monoclonal antibodies with lymphocytes from the patients, presence of IgM antibody to HHV-6 and significant elevation in IgG antibody. Reactivation of HHV-6 may contribute to immune disturbances, either by interfering with function of immunocytes or by polyclonal stimulation of T-cells, which, in turn, lead to disease manifestations.