NEUROPSYCHOLOGICAL TESTING

我们的工作集中在描述认知的各个方面 精神分裂症的失败。我们特别尝试： 1.检查记忆功能。研究正在进行中，正在检查 启动中的远距离记忆、自传体记忆和内隐记忆 范例。其他研究包括使用 不同干扰条件下的帕森-彼得森范式。 2.检查特异性。我们正在评估双胞胎的认知功能 不和谐的情感障碍，不和谐的双胞胎精神分裂症， 颞叶癫痫、创伤性脑损伤(在NRH)和情感性 无序。 3.考察执行功能。涉及延迟的多项任务 反应和老年学习都是为了确定 并在正电子发射计算机断层扫描中用作认知激活剂 SPECT。 4.观察抗精神病药的疗效。我们正在比较病人的 在他们接受治疗时的神经心理测试的表现 氯氮平、氟哌啶醇和安慰剂。 5.考查航向。我们正在评估精神分裂症和躁郁症 横断面设计的患者和精神分裂症患者 纵向设计。 6.研究认知增强策略。我们正在研究 苯丙胺对注意和执行任务的影响。 7.考察运动障碍、认知障碍之间的关系 精神损害和精神病理学。我们正在对MZ双胞胎进行密集评估 多发性抽动症的神经心理学、精神病理学和核磁共振成像和 迟发性运动障碍和肌张力障碍患者。 8.探讨认知与精神病理学的关系。《查普曼报》 快感缺乏症、知觉偏差和神奇思维的标尺 确定脑与脑之间有意义的联系的可能性 异常和心理异常。

Our work has focused on characterizing various facets of cognitive failure in schizophrenia. We have attempted in particular: 1. To examine memory function. Studies are underway which are examining remote or autobiographical memory and implicit memory in a priming paradigm. Other studies involve assessing working memory using the Parson Petersen paradigm with different interference conditions. 2. To examine specificity. We are assessing cognitive functions in twins discordant for affective disorder, twins discordant for schizophrenia, temporal lobe epilepsy, traumatic brain injury (at NRH), and affective disorder. 3. To examine executive function. A number of tasks that involve delayed response and senile learning have been developed both to ascertain performance profiles and to be used as cognitive activators in PET and SPECT. 4. To examine the effects of neuroleptics. We are comparing patients' performance on neuropsychological tests while they am receiving clozapine, haloperidol, and placebo. 5. To examine course. We are assessing schizophrenic and bipolar patients in cross-sectional designs and schizophrenic patients in a longitudinal design. 6. To examine cognitive enhancing strategies. We are examining the effects of amphetamine on attentional and executive tasks. 7. To examine the relation between movement disorder, cognitive impairment, and psychopathology. We are intensively assessing MZ twins with Tourette's syndrome on neuropsychology, psychopathology, and MRI and patients with Tardive dyskinesia and dystonia. 8. To examine the relation to cognition to psychopathology. The Chapman Scales of anhedonia, perceptual aberration, and magical ideation offer the possibility of ascertaining meaningful relations between brain abnormalities and psychological abnormalities.