PHARMACOLOGY OF ANXIETY

重组人焦虑相关行为的基因分析已经开始 C57BL/6J×A/J杂交的近交系。小鼠品系的筛选 显示了C57BL/6J和A/J之间最大的行为差异 杰克逊实验室的。这个杂交组合也是一个很好的选择，因为30个RI菌株 都是从这个十字架上保存在杰克逊的。基线亮-暗 转换，在安定后增加转换，开放领域 行走，在C57BL/6J中发现较高，在A/J中较低。 A/J对戊四氮和B-CCM的诱导更敏感。 癫痫发作。已完成对这些参数的行为测试 11株RI菌株，9株进行了部分检测，其余菌株现在正在进行检测 到达，以创建一个足以进行统计分析的数据库 可能调节小鼠焦虑相关行为的基因数量。

Genetic analysis of anxiety-related behaviors has begun for recombinant inbred strains of the C57Bl/6J x A/J cross. A screen of mouse strains showed the biggest behavioral differences between the C57Bl/6J and the A/J from Jackson Labs. This cross is also a good choice because 30 RI strains are maintained at Jackson from this cross. Baseline light-dark transitions, increase in transitions after diazepam, open field ambulation, were found to be high in the C57Bl/6J and low in the A/J. The A/J were more sensitive to pentylenetetrazol and to B-CCM on induction of seizures. Behavioral testing on these parameters has been completed for 11 RI strains, 9 are partially tested, and the remaining strains are now arriving, to create a data base sufficient for statistical analysis of number of genes which may be mediating anxiety-related behaviors in mice.