COMPARATIVE SELF-ADMINISTRATION (MONKEYS AND HUMAN)--NICOTINE AND COCAINE

这是一个与BPL合作的项目，在这个项目中，人类研究 是在住宅研究单位和平行动物上进行的 研究是在BPL进行的。自我管理的运用 (Sa)研究范式允许对相对贡献进行评估 环境和药理因素对自我给药的影响 毒品。在松鼠、猴子和人类身上进行的平行比较研究 哪些受试者有机会自我管理可比 可卡因和尼古丁的剂量在相似的行为时间表和 实验条件也提供了一种评估通用性的方法 影响药物SA的生物变量。这项研究表明， 反应在人类受试者身上保持不变。刺激物是 与注射可卡因相关的条件性强化 对人类的影响的方式类似于这些 这种效应在松鼠猴子身上也会产生。这些研究还 证明了一种在人类中使用药物SA的研究策略 受试者可以提供单次注射的所有重要信息 研究，还提供了关于直接增强效果的信息 可与动物药物的大碱基相媲美的化合物 莎拉。数据采集已经完成，只需要进行最终的 出版前的分析。

This was a collaborative project with the BPL in which the human research was conducted on the Residential Research Unit and parallel animal studies were conducted in the BPL. The use of the self-administration (SA) study paradigm permitted an assessment of the relative contribution of environmental and pharmacologic factors to the self-administration of drugs. Parallel comparative studies in squirrel monkeys and humans in which subjects are given the opportunity to self-administer comparable doses of cocaine and nicotine under similar behavioral schedules and experimental conditions also provide a means to assess the generality of biological variables influencing drug SA. This research has shown that responding is maintained in human subjects. The stimuli that are associated with injections of cocaine develop conditioned reinforcing effects in the humans in a manner similar to the manner in which these effects develop in squirrel monkeys. These studies have also demonstrated that a research strategy employing drug SA in human subjects can yield all of the important information of single-dose studies, and also, provide information on the direct reinforcing effects of the compound which may be compared to the large base of animal drug SA. Data collection has been completed and need only to undergo final analyses before publication.