课题基金 / 基金详情

OXIMES RESEARCH PROJECT

OXIMES RESEARCH PROJECT
肟研究项目
批准号：
3855861
负责人：
M P DIETER
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3855861
关键词：
alcohols bone marrow exam chemical carcinogen chemical carcinogenesis drug metabolism environmental toxicology oximes toxin metabolism water pollution

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相关文献

中文摘要
翻译
提名了肟类化学品的代表性化合物 由于其毒性和潜在致癌性尚未得到 很好的描述。 环己酮肟的接触毒性研究 和丁酮肟在别处有报道。 此外，内部研究 研究了环己酮肟或丁酮肟对 乙二醇烷基醚的毒性是负面的，尽管据报道， 肟可能会干扰酒精代谢。 没有进一步的内部 预计将对肟进行研究，除非常见的 对骨髓细胞具有潜在毒性的代谢物在 正在进行的代谢研究和数据审查证明， 调查
英文摘要
Representative compounds from the oxime class of chemicals were nominated by NCI because their toxicity and potential carcinogenicity had not been well characterized. The contract toxicity studies of cyclohexanone oxime and butanone oxime are reported elsewhere. In addition, in-house research investigations of the influence of cyclohexanone oxime or butanone oxime on glycol alkyl ether toxicity were negative, even though it was reported that oximes might interfere with alcohol metabolism. No further in-house research studies with the oximes are anticipated, unless a common metabolite with potential toxicity to bone marrow cells is identified in ongoing metabolism studies, and review of the data, justifies further investigation.
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