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MECHANISMS OF HISTAMINE RELEASE

MECHANISMS OF HISTAMINE RELEASE
组胺释放机制
批准号：
3854157
负责人：
R SIRAGANIAN
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3854157
关键词：
antibody receptor antihistamines basophils calcium transporting ATPase disease /disorder model histamine release host organism interaction immunoglobulin E immunoregulation inflammation ionophores laboratory rat leukemia lymphocyte proliferation mast cell secretion tissue /cell culture

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中文摘要
翻译
肥大细胞和嗜碱性粒细胞释放组胺的研究 参与炎症的免疫学机制之一。它也是 一个细胞分泌的模型。在使用的组胺释放剂中 是IgE抗体、其他促分泌物、LHRH多肽和钙 离子浮子A23187。培养的大鼠嗜碱性白血病细胞用作 免疫球蛋白E受体及其生化变化的研究模型 细胞激活。可以获得大量的细胞用于生化 研究和生化变异已经被挑选出来，这些变异在 在细胞激活和分泌途径中的不同位置。
英文摘要
Histamine release from mast cells and blood basophils is being studied as one of the immunological mechanisms involved in inflammation. It is also a model for cell secretion. Among the histamine releasing agents employed are IgE antibody, other secretagogues, LHRH peptides, and the calcium ionophore A23187. Cultured rat basophilic leukemia cells are used as a model for the studies of the IgE receptor and of biochemical changes during cell activation. Large numbers of cells can be obtained for biochemical studies and biochemical variants have been selected which are defective at different sites in the pathway of cell activation and secretion.
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PRODUCTION OF HYBRIDOMAS
PRODUCTION OF HYBRIDOMAS
PRODUCTION OF HYBRIDOMAS
MECHANISMS OF HISTAMINE RELEASE
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