ROLE OF NEUROPEPTIDES AND BIOGENIC AMINES IN NEUROENDOCRINE REGULATION

血管紧张素Ⅱ受体： 脑血管紧张素II受体被鉴定为两种截然不同的 亚型：AT1和AT2。每个亚型都是异质性的。它们发生得很早 胚胎第18天，发育不同，有不同的鸟嘌呤 核苷酸和百日咳毒素敏感性。 大脑动脉血管紧张素II受体为AT2型。 大脑、大脑动脉和垂体血管紧张素受体在 动情周期，由雌激素调节。 大鼠交感神经节含有与PI周转偶联的AT1受体。 大量的AT2和少量的AT1受体存在于 胎儿组织。胎儿AT1而不是AT2受体与猪偶联 营业额。 大鼠胚胎和大鼠主动脉中血管紧张素受体的主要比例 未成熟大鼠属于AT2亚型。 大鼠脾中的血管紧张素II受体属于AT1亚型。 褪黑素受体： 大脑和尾动脉褪黑素受体在发情过程中的变化 周期，并受雌激素调节。 高血压大鼠的动脉褪黑激素受体较低。 心钠素受体：不同的亚型 脉络丛和穹隆下器。C-心钠素 受体非常有选择性地定位在大鼠的大脑中。 这些受体在胎儿边缘系统皮质中含量很高。 胰岛素样生长因子-I受体。胰岛素样生长因子-I受体的发育 在大鼠和金黄地鼠的下丘脑核团和脑垂体部 腺体。甲状腺激素和雌激素对大鼠IGF-I受体的调节作用 下丘脑核团。

Angiotens II receptors: Brain angiotens II receptors have been characterized as two distinct subtypes: AT1 and AT2. Each subtype is heterogenous. They occur as early as embryonic day 18, develop differently and have differential guanine nucleotide and pertussis toxin sensitivities. Cerebral artery angiotensin II receptors are of the AT2 type. Brain, cerebral artery, and pituitary angiotensins receptors vary during the estrous cycle and are regulated by estrogens. Rat sympathetic ganglia contain AT1 receptors coupled to PI turnover. Large numbers of AT2, and smaller amounts of AT1, receptors are present in fetal tissues. Fetal AT1, but not AT2, receptors are coupled to PI turnover. A major proportion of angiotensin receptors in aortas from rat fetus and immature rats are of the AT2 subtype. Angiotensin II receptors in the rat spleen are of the AT1 subtype. Melatonin receptors: Cerebral and caudal artery melatonin receptors vary during the estrous cycle and are regulated by estrogens. Arterial melatonin receptors are lower in hypertensive rats. Atrial natriuretic peptide receptors: There are different subtypes in the choroid plexus and subfornical organ. C-atrial natriuretic peptide receptors are very selectively localized in the rat brain. These receptors are very high in fetal limbic system cortex. Insulin-like growth factor (IGF-I) receptors. IGF-I receptor development was characterized in rat and hamster hypothalamic nuclei and pituitary gland. Both thyroid hormones and estrogen regulate IGF-I receptors in rat hypothalamic nuclei.